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Food Derived Biomolecules in Reducing the Risk of Diseases
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Food Derived Biomolecules in Reducing the Risk of Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 8996

Special Issue Editor

Dr. Furong Tian

E-Mail Website
Guest Editor
School of Food Science Environmental Health, Technological University Dublin, Dublin, Ireland
Interests: disease diagnostics and treatment; smart multifunctional molecular imaging nanoprobes; ultrasensitive detection technologies and devices; tumor biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Food derived biomolecules implicated in reducing the risk of chronic diseases represent an important issue, both for scientists and for consumers. Food derived biomolecules may have a positive impact on body weight, blood pressure and glucose metabolism control, endothelial damage, lipid profile improvement, inflammation, oxidative stress. This Special Issue will be dedicated to new perspectives in biochemical and functional properties of foods and other natural products. Emerging food processing and preservation methods can enhance antioxidant, anti-inflammatory, anti-atherosclerotic, antihypertensive, anti-cancer, immune boosting. Targeted techno-functional properties are used for new functional food product development against metabolic diseases and beyond, diabetes and cancer. Subjects that will be discussed in this Special Issue will focus not only on modern methods, technologies, and further handling of food prior to its consumption, but also on the verification of new preservation/packaging development and human health studies.

Dr. Furong Tian
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food derived biomolecules
  • chronic diseases
  • antioxidant
  • anti-inflammatory

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Published Papers (2 papers)

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Review

19 pages, 1315 KiB  
Review
The Putative Antidiabetic Effect of Hypericum perforatum on Diabetes Mellitus
by Aikaterini Theodorakopoulou, Ioanna Pylarinou, Ioanna A. Anastasiou and Nikolaos Tentolouris
Int. J. Mol. Sci. 2025, 26(1), 354; https://doi.org/10.3390/ijms26010354 - 3 Jan 2025
Cited by 1 | Viewed by 1200
Abstract
Diabetes mellitus (DM), a global disease that significantly impacts public health, has become increasingly common over time. In this review, we aim to determine the potential benefits of St. John’s Wort (SJW) as an adjunct therapy for DM. We gathered information from studies [...] Read more.
Diabetes mellitus (DM), a global disease that significantly impacts public health, has become increasingly common over time. In this review, we aim to determine the potential benefits of St. John’s Wort (SJW) as an adjunct therapy for DM. We gathered information from studies conducted in vitro, in vivo, and in humans. In vitro studies investigated the concentrations of SJW extracts capable of inhibiting certain enzymes or factors involved in the inflammatory pathway, such as the β-signal transducer and activator of transcription 1, nuclear factor κB, methylglyoxal, and oxidative stress (OS). The extract was found to have positive effects on OS and anti-inflammatory properties in DM, suggesting it could serve as a protective agent against diabetic vascular complications, cell damage, and apoptosis. According to in vivo research, the essential components of the extract can stimulate thermogenesis in adipose tissue, inhibit several key inflammatory signaling pathways, and delay the early death of pancreatic β cells, all of which contribute to combating obesity. The extract may also help treat prediabetes and significantly reduce neuropathic pain. Human studies have also confirmed some of these results. However, some of the plant’s side effects need further investigation through clinical research before it can be used to treat DM. Full article
(This article belongs to the Special Issue Food Derived Biomolecules in Reducing the Risk of Diseases)
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30 pages, 1979 KiB  
Review
Nigella sativa: A Comprehensive Review of Its Therapeutic Potential, Pharmacological Properties, and Clinical Applications
by Adina Alberts, Elena-Theodora Moldoveanu, Adelina-Gabriela Niculescu and Alexandru Mihai Grumezescu
Int. J. Mol. Sci. 2024, 25(24), 13410; https://doi.org/10.3390/ijms252413410 - 14 Dec 2024
Cited by 4 | Viewed by 7099
Abstract
Nigella sativa (NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or black seed. This plant has been used since ancient times due to its therapeutic properties and has proven effective in gastrointestinal, respiratory, cardiovascular, infectious, and [...] Read more.
Nigella sativa (NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or black seed. This plant has been used since ancient times due to its therapeutic properties and has proven effective in gastrointestinal, respiratory, cardiovascular, infectious, and inflammatory conditions. In this review, the aim is to highlight the therapeutic effects of the plant known in Arab countries as “the plant that cures any disease”, which are provided by the phytochemical compounds in its composition, such as thymoquinone, p-cymene, α-thujene, longifolene, β-pinene, α-pinene, and carvacrol. These compounds confer an antioxidant effect to the seeds, leading to a significant decrease in ROS and a potent anti-inflammatory effect. Also, in this review, the aim is to highlight that NS seeds may have a synergistic effect with other drugs, such as chemotherapeutic agents or antibiotics, which may lead to a reduction in the therapeutic dose, may have an improved effect, and could lead to overcoming obstacles such as drug resistance. The studies provided in this review showed that NS has the potential to be a therapeutic agent both as a monotherapy and as an adjuvant. Although there are studies demonstrating the therapeutic properties of NS, there is a need for much more extensive research and more clinical trials with clearly established objectives so that the mechanism of action of the active substances in NS is much better understood. With the data provided so far, NS can be used in food and drug production in small quantities and can be administered for short periods. Further investigations may lead to an understanding of the therapeutic profile and the most effective mode of administration, as well as a clearer perspective on the toxicological profile of NS. Full article
(This article belongs to the Special Issue Food Derived Biomolecules in Reducing the Risk of Diseases)
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