New Insights of Biomarkers in Neurodegenerative Diseases

Dear Colleagues,

Biomarkers are objectively measured biological indices of normal or pathogenic biological processes. They are associated with specific clinical endpoints: e.g., diagnostic biomarkers reflect the clinical state of an individual (whether a person has a particular disease or not), susceptibility biomarkers measure the risk of developing a disorder, prognostic biomarkers are used to determine disease progression, predictive biomarkers are utilized to identify potential responders to specific interventions, and so on. Occasionally, given their well-established clinical relevance, biomarkers are used as substitute endpoints, instead of clinical outcomes. Biological markers are considered to play an important role in clinical research and practice. In the context of neurogenerative disorders, they are necessary to improve the identification of individuals at high-risk of developing a condition and the diagnostic accuracy and categorization of patients. Currently, among neurodegenerative disorders, biomarkers specific for Alzheimer’s disease have been studied more rigorously. This collection aims to cover the most recent advances in the field of biomarkers for neurodegenerative disorders. Any types of manuscripts supported by the Journal—original research articles, brief reports, communications, narrative reviews, systematic reviews, and meta-analyses - pertaining to this topic are welcome. Potential topics include, but are not limited to: Imaging, CSF, blood and urine-based biomarkers; Clinical relevance of biomarkers; Potential use and limitations of current biomarkers; Biomarkers as surrogate endpoints; Biomarkers in drug development; Biological and clinical markers.

Dr. Ioannis Liampas
Guest Editor

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