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Proteomics in Diagnosis and Treatment of Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (22 September 2022) | Viewed by 1862

Special Issue Editor


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Guest Editor
Sant Pau Memory Unit, Neurology Department, Institute of Biomedical Research (IIB)-Sant Pau, Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain
Interests: proteomics; genomics; biomarkers; neurodegenerative disease

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases represent one of the major health challenges facing modern society. Over the last decade, technological advances have led to a gradual adoption of proteomic strategies to identify proteoforms that are involved in early disease pathways. In this special issue, we welcome original contributions and review articles related to studies that employ a proteomics strategy to address the critical need for diagnostic biomarkers and new drug targets for neurodegenerative diseases. We welcome both non-targeted and targeted proteomics studies with technology including but not limited to MS imaging, iTRAQ, SWATH, PRM, SRM. SILK or in silico network-based mapping with an emphasis on the use of patient-derived tissue or biofluids. This series of publications will stimulate conversation and advance research toward the potential prevention of these devastating diseases, by improving diagnosis, clinical trial design and drug target identification.

Dr. Olivia Belbin
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Review

13 pages, 285 KiB  
Review
Peptidomic Approaches and Observations in Neurodegenerative Diseases
by Besnik Muqaku and Patrick Oeckl
Int. J. Mol. Sci. 2022, 23(13), 7332; https://doi.org/10.3390/ijms23137332 - 30 Jun 2022
Cited by 3 | Viewed by 1532
Abstract
Mass spectrometry (MS), with its immense technological developments over the last two decades, has emerged as an unavoidable technique in analyzing biomolecules such as proteins and peptides. Its multiplexing capability and explorative approach make it a valuable tool for analyzing complex clinical samples [...] Read more.
Mass spectrometry (MS), with its immense technological developments over the last two decades, has emerged as an unavoidable technique in analyzing biomolecules such as proteins and peptides. Its multiplexing capability and explorative approach make it a valuable tool for analyzing complex clinical samples concerning biomarker research and investigating pathophysiological mechanisms. Peptides regulate various biological processes, and several of them play a critical role in many disease-related pathological conditions. One important example in neurodegenerative diseases is the accumulation of amyloid-beta peptides (Aβ) in the brain of Alzheimer’s disease (AD) patients. When investigating brain function and brain-related pathologies, such as neurodegenerative diseases, cerebrospinal fluid (CSF) represents the most suitable sample because of its direct contact with the brain. In this review, we evaluate publications applying peptidomics analysis to CSF samples, focusing on neurodegenerative diseases. We describe the methodology of peptidomics analysis and give an overview of the achievements of CSF peptidomics over the years. Finally, publications reporting peptides regulated in AD are discussed. Full article
(This article belongs to the Special Issue Proteomics in Diagnosis and Treatment of Neurodegenerative Diseases)
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