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Special Issue "Proteomics and Nucleotide Profiling as Tools for Biomarker and Drug Target Discovery"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 15 February 2020.
2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Interests: discovery based and targeted proteomics; tandem mass spectrometry; protein biomarkers; lymphoma; eye diseases; cardiovascular diseases
Interests: in vitro diagnostics; endogenous nanoparticles; miRNA; biomarker discovery; complications of pregnancy; gynaecological oncology; research quality management systems
2. Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark
Interests: ocular proteomics; ophthalmology; biomarkers (diagnostic, prognostic, predictive, etc.); proteomics methods (2D-PAGE, LC-MS, protein arrays); discovery based proteomics; drug targets; bioinformatics
Separate developments of a wide variety of techniques including two-dimensional gel electrophoresis (2D-PAGE), mass spectrometry (MS), construction of databases with structural information as well as the development of software applications and computer science formed the basis for the field of proteomics some decades ago. The field has shown tremendous advancement ever since, especially more recently. Proteins originate from protein-coding RNA. More recently, non-coding RNAs have been shown to be important regulators of cell function, biomarkers of pathology and as putative clinical interventions.
This Special Issue addresses the challenges in the application of proteomic analysis and nucleotide profiling to support clinical decisions based on the mapping of disease-associated protein and nucleotide changes that may highlight protein and nucleotide candidates as biomarkers or drug targets. Challenges include the establishment of protocols to reliably prepare proteins or nucleotides from a variety of sample sources including cell preparations, frozen solid tumours or formalin-fixed paraffin-embedded (FFPE) tissue to liquids like plasma or cerebrospinal fluid that may each present heterogeneity or a high dynamic range of protein concentrations, different posttranslational modifications, etc. Descriptions of efforts to address such issues as well as technological developments and advances in software applications are highly welcome.
This Special Issue calls for original research manuscripts, communications and reviews that describe the current knowledge and future perspectives in the development of proteomics and nucleotide-based techniques to reveal candidate biomarkers or drug targets for diseases. Topics include but are not limited to the keywords below.
Prof. Dr. Bent Honoré
Prof. Dr. Gregory Edward Rice
Prof. Dr. Henrik Vorum
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Sample preparation (frozen tissue, FFPE tissue, cells, plasma, CSF, urine, etc.)
- Proteomic methods (2D-PAGE, LC-MS, protein arrays)
- Discovery-based and targeted proteomics
- SWATH (sequential windowed acquisition of all theoretical mass spectra) MS
- Biomarkers (diagnostic, prognostic, predictive, etc.)
- Drug targets
- nanoparticle methods