Role of Bioactive Phytochemicals in Metabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 14080
Special Issue Editors
Interests: phytocompounds; phenolic compounds; animal cell culture; cell signaling; nuclear receptors; apoptosis; cytoprotection; lipid and carbohydrates metabolism
Special Issues, Collections and Topics in MDPI journals
Interests: antidiabetic activity in the group of GPCR ligands; inhibitors of small GTPases prenylation; molecular mechanism of action of phytochemicals (fatty acids and their derivatives)
Special Issue Information
Dear Colleagues,
The constant increase in the incidence of metabolic diseases, including cardiovascular disease, obesity and type 2 diabetes, prompts scientists to search for new therapeutics that have the ability to improve the metabolism of lipids and carbohydrates. What is more, epidemiologic evidence suggests that people with diabetes are at a significantly greater risk of many forms of cancer. In spite of the great progress in the field of medicinal chemistry that has allowed for the synthesis of a huge amount of novel potential drug molecules, the variety of complications resulting from their prolonged usage encouraged the search for less harmful plant-derived substitutes. There is growing evidence that bioactive phytocompounds present in our diet, mainly secondary metabolites, can prevent multiple pathologies with different mechanisms, i.e., by the reduction in oxidative stress, modulation of cell signaling responses, regulation of certain genes expression, or even direct interaction with some proteins. Therefore, plant-derived natural products are significant as ingredients of functional foods or sources of medicinal agents and as models for the design of new remedies. While phenolic compounds deserve a special attention, more so than other bioactive phytocomponents, the regulatory effects of other plant metabolites, i.e., lipids, are still partially known. Thus, the aim of this Special Issue is to highlight recent achievements in the field of dietary bioactive phytochemicals, their specific mechanisms of action, and their use in the prevention of chronic diseases.
Dr. Malgorzata Zakłos-Szyda
Dr. Edyta Gendaszewska-Darmach
Guest Editors
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Keywords
- bioactive phytochemicals
- phenolic compounds
- bioactive lipids
- biological activity
- mechanism of action
- chronic diseases
- functional foods ingredients.
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