Mechanisms of Metastasis in Pancreatic Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 2601
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive disease with limited options in terms of effective therapies. The five-year survival rate for PDAC patients is estimated at 7%, making it the sixth most common cancer-related cause of death even though it is the twelfth in incidence. A major reason for this devastating outcome is the high metastatic rate of the disease combined with a lack of effective strategies for early detection and treatment of metastasis. Nearly 80% of the diagnosed patients have regional or distal metastasis. At autopsy, it was found that over 80% of PDAC patients have liver metastasis and nearly 45% have lung metastasis.
Preventing and/or treating PDAC metastasis will significantly improve the outcome of pancreatic cancer drugs. Therefore, understanding the mechanism of metastasis is crucial to overcome this burden. This Special Issue aims to develop novel insights to overcome PDAC metastasis. This includes novel concepts for the detection, prevention, and treatment of metastasis.
Dr. Mouad Edderkaoui
Guest Editor
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Keywords
- pancreatic cancer
- metastasis
- chemo-resistance
- drug development
- risk factors of cancer
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