Pathophysiology of Formin Proteins: From Single Molecules to Model Organisms and Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 2120
Special Issue Editor
Special Issue Information
Dear Colleagues,
The formin family comprises several different proteins in both multi- and uni-cellular eukaryotes. Over the past three decades, great strides have been made towards elucidating the functions of individual formins as well as the divergence among family members.
It is now clear that all eukaryotes rely on one or more formin-family proteins to locally modulate actin and microtubule dynamics. Although all formin-family proteins may regulate the cytoskeleton, different members participate in specific developmental and pathophysiological processes.
Formins regulate morphogenetic processes ranging from maintenance of membrane-bound organelles to vesicle trafficking and membrane protrusion, and control the establishment of polarity for asymmetric cell division and directed cell migration. Formins also affect cytosolic signal transduction pathways and gene transcription within the nucleus. Recent evidence suggests that formins may have additional nuclear cell cycle-related and apoptosis-related functions. Finally, both invertebrate and mammalian formins contribute to embryonic development and tissue homeostasis. Not surprisingly, mutations perturbing formins’ activity and expression are associated with a growing number of inherited diseases and cancers.
We invite authors to contribute high-quality research and review articles that illustrate current efforts to understand the pathophysiological functions and the regulation of formins at the molecular, cellular, tissue, and organismal levels.
Dr. Metello Innocenti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- formins
- cytoskeleton
- cancer
- actin
- microtubules
- model organisms
- pathophysiology
- human diseases
