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Novel Therapeutic Approaches for Migraine Headaches

Special Issue Editors


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Guest Editor
Department of Neuroscience, University of Padua, 35122 Padova, Italy
Interests: minimally invasive approaches for migraines; occipital neuralgia; nerve decompression surgery; migraines; cluster headaches; botulinum toxin

E-Mail Website
Guest Editor
Department of Neuroscience, University of Padua, 35122 Padova, Italy
Interests: minimally invasive approaches for migraines; occipital neuralgia; nerve decompression surgery; migraines; cluster headaches; botulinum toxin

Special Issue Information

Dear Colleagues,

Migraines and chronic headaches remain among the most disabling conditions. Novel approaches, ranging from new pharmacologic and molecular therapeutics to novel, more effective protocols of already-used drugs such as botulinum toxin and anti-CGRPs are highly warranted to help migraines. In some conditions such as occipital neuralgia, normally considered very rare, there is a clear dysfunction of the occipital nerves, but there is a lack of effective treatment options, with this condition remaining largely underestimated. Cluster headaches are rarer but are among the worst and most intense types of headaches; more effective strategies of treatment are highly needed.

This Special Issue aims to bring together clinical experts to develop guidelines for the diagnosis and treatment of migraine, chronic headaches, cluster headaches occipital neuralgia and neurological disorders, focusing on insights and advances at the genetic and molecular levels.

Dr. Giorgio Pietramaggiori
Dr. Saja Scherer
Guest Editors

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Keywords

  • migraines
  • chronic headaches
  • cluster headaches
  • occipital neuralgia
  • neuralgia
  • occipital nerve dysfunction
  • nerve damage
  • botulinum toxin

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Published Papers (1 paper)

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Research

11 pages, 1145 KiB  
Article
Hypersensitivity of Intrinsically Photosensitive Retinal Ganglion Cells in Migraine Induces Cortical Spreading Depression
by Eiichiro Nagata, Motoharu Takao, Haruki Toriumi, Mari Suzuki, Natsuko Fujii, Saori Kohara, Akio Tsuda, Taira Nakayama, Ayana Kadokura and Manaka Hadano
Int. J. Mol. Sci. 2024, 25(14), 7980; https://doi.org/10.3390/ijms25147980 - 22 Jul 2024
Cited by 2 | Viewed by 1662
Abstract
Migraine is a complex disorder characterized by episodes of moderate-to-severe, often unilateral headaches and generally accompanied by nausea, vomiting, and increased sensitivity to light (photophobia), sound (phonophobia), and smell (hyperosmia). Photophobia is considered the most bothersome symptom of migraine attacks. Although the underlying [...] Read more.
Migraine is a complex disorder characterized by episodes of moderate-to-severe, often unilateral headaches and generally accompanied by nausea, vomiting, and increased sensitivity to light (photophobia), sound (phonophobia), and smell (hyperosmia). Photophobia is considered the most bothersome symptom of migraine attacks. Although the underlying mechanism remains unclear, the intrinsically photosensitive retinal ganglion cells (ipRGCs) are considered to be involved in photophobia associated with migraine. In this study, we investigated the association between the sensitivity of ipRGCs and migraines and cortical spreading depression (CSD), which may trigger migraine attacks. The pupillary responses closely associated with the function of ipRGCs in patients with migraine who were irradiated with lights were evaluated. Blue (486 nm) light irradiation elicited a response from ipRGCs; however, red light (560 nm) had no such effect. Melanopsin, a photosensitive protein, phototransduces in ipRGCs following blue light stimulation. Hypersensitivity of ipRGCs was observed in patients with migraine. CSD was more easily induced with blue light than with incandescent light using a mouse CSD model. Moreover, CSD was suppressed, even in the presence of blue light, after injecting opsinamide, a melanopsin inhibitor. The hypersensitivity of ipRGCs in patients with migraine may induce CSD, resulting in migraine attacks. Full article
(This article belongs to the Special Issue Novel Therapeutic Approaches for Migraine Headaches)
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