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Natural Products in Diabetes: From Molecular Mechanisms to Novel Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 137

Special Issue Editor

Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wailong, Taipa, Macao, China
Interests: natural products; diabetic kidney disease; nephrotic syndrome; diabetes; pharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes mellitus is a burgeoning global health challenge. Despite the availability of synthetic anti-diabetic drugs, the disease's prevalence necessitates the exploration of novel therapies. Inspired by the vast and untapped therapeutic potential of natural products, where traditional and indigenous systems of medicine have played a crucial role in managing diabetes, this Special Issue is devoted to "Natural Products and Diabetes."

The focus lies on understanding the mechanisms of action, efficacy, safety, and therapeutic potential of natural products in diabetes management. These naturally occurring compounds, derived from various sources such as plants, fungi, algae, and bacteria, possess a wide range of bioactive properties, including anti-diabetic activity. They have been known to help manage blood sugar levels, improve insulin sensitivity, and even provide antioxidant support, which play a crucial role in preventing diabetic complications.

This Special Issue invites original research articles, reviews, and clinical study reports. The topics of interest include, but are not limited to, the following:

  • Bioactive compounds from natural sources with potential anti-diabetic properties.
  • Experimental and clinical studies investigating the efficacy and safety of natural products in diabetes intervention.
  • Mechanistic studies elucidating the pathways and targets involved in the anti-diabetic action of natural products.
  • Exploration of natural products in the prevention of diabetes-related complications.
  • Studies on formulation and development of natural-product-derived anti-diabetic drugs.

This Special Issue also encourages submissions that discuss the challenges, such as standardization and quality control, bioavailability improvement, and regulatory aspects, in translating the traditional use of these natural substances into evidence-based medicine.

We believe that this Special Issue will provide a platform to discuss the current progress, future prospects, and challenges in the field of natural products and diabetes. This Special Issue will serve as an essential scientific repository that will hopefully stimulate further research and development into natural-product-based anti-diabetic therapies.

We look forward to furthering our understanding of the interactions between natural products and diabetes and bringing forth valuable insights to revolutionize diabetic care.

Dr. Youhua Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural products
  • diabetes mellitus
  • anti-diabetic activity
  • bioactive compounds
  • insulin sensitivity
  • traditional medicine
  • medicinal plants
  • diabetes management
  • mechanistic studies
  • anti-diabetic drugs
  • therapeutic potential
  • clinical studies
  • blood sugar regulation
  • antioxidant support
  • diabetes-related complications
  • quality control and standardization

Published Papers

This special issue is now open for submission.
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