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Special Issue "New Strategies of Neuroprotection and Repair in the Developing Brain"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 24955
Special Issue Editor
PROTECT, Inserm 1141, Université Paris Diderot, Sorbonne Paris Cité, 75019 Paris, France
PremUP Foundation, 75014 Paris, France
Interests: perinatal brain damage; neonatal brain damage
Special Issue Information
Every year, 30 million infants worldwide are delivered after intra-uterine growth restriction (IUGR), and 15 million are born preterm. These two conditions are the leading causes of brain injury responsible for neurocognitive and behavioral disorders in more than 9 million children each year. Systemic inflammation, microglial activation, astroglial reaction, and their consequences on neuronal networks and connectivity have been identified as the main factors responsible for neurodevelopmental impairments. While strategies for protecting the developing brain and promoting its repair following injury have been extensively investigated in preclinical studies, most pharmacological candidates struggle to demonstrate a substantial beneficial effect to prevent brain lesions and their long-lasting neurodevelopmental consequences in infancy and adulthood. Several shortcomings impede clinical translation of preclinical promising strategies, including biological relevance in humans, dosage, timing, and outcomes used for assessing intervention. Nevertheless, many improvements have been observed in the last two decades, and neuroprotection of the developing brain has never appeared so closed, especially by refining new tools for assessing brain functions and by combining several strategies. This Special Issue will update the state-of-the-art in these strategies based on molecular mechanisms supporting their relevance.
Prof. Dr. Olivier Baud
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Immature brain
- Microglial activation
- Oligodendroglial lineage
- Brain imaging