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Special Issue "Neurons and Surrounding Environments in Neurological Disorders and Brain Damages"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editors

Prof. Dr. Yunjong Lee

Guest Editor
Division of Pharmacology, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea
Interests: Parkinson’s disease; Animal model; High throughput screening; Diagnostic biomarkers; Neuroinflammation
Prof. Dr. Seung Pil Yun

Guest Editor
Department of Pharmacology, School of Medicine, Gyeongsang National University, 15 Jinjudae-ro 816, Jinju, 52727, Korea
Interests: Neuro-iflammation; Neurodegenrative disease; Stem cell application for brain: Relationship CNS and peripheral organ inflammation; Brain cancer

Special Issue Information

Dear colleagues,

Diverse neurological disorders as well as brain damage affect individuals tremendously by causing reversible or irreversible damage in neural circuits that are critically important for human behavior and healthy lifestyle. Recently, many researchers have reported significant pathological and physiological roles by multiple non-neuronal environments (neurotrophic and inflammatory factors by microglia-astrocytes, circulating metabolites by gut microbiota, infiltration of peripheral lymphocytes, brain tumors, etc.) in the maintenance of brain function. Novel therapeutic and diagnostic strategies for complex neurological disorders could be achieved by gaining a broad understanding of surrounding environments as well as neuronal alterations themselves.

In this regard, the aim of this Special Issue is to report the recent progress achieved from studies of the central nervous system influenced by various organ dysfunctions or peripheral pathological conditions, including cancers, and systemic inflammation. This Special Issue also welcomes translational and basic research on molecular alterations within neurons during diverse neurological problems.

Prof. Dr. Yunjong Lee
Prof. Dr. Seung Pil Yun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Neurological disorder
  • Alzheimer's disease
  • Parkinson's disease
  • Brain damage
  • Stroke
  • Cancer
  • Psychosis
  • Autism
  • Depression
  • Neurodegenerative biomarker
  • Organ dysfunctions
  • Systemic inflammation
  • Microglia
  • Astrocyte

Published Papers (2 papers)

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Research

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Open AccessArticle
The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4′-F-PCP) in Rodents
Int. J. Mol. Sci. 2020, 21(13), 4631; https://doi.org/10.3390/ijms21134631 - 29 Jun 2020
Abstract
The dissociative anesthetic phencyclidine (PCP) and PCP derivatives, including 4′-F-PCP, are illegally sold and abused worldwide for recreational and non-medical uses. The psychopharmacological properties and abuse potential of 4′-F-PCP have not been fully characterized. In this study, we evaluated the psychomotor, rewarding, and [...] Read more.
The dissociative anesthetic phencyclidine (PCP) and PCP derivatives, including 4′-F-PCP, are illegally sold and abused worldwide for recreational and non-medical uses. The psychopharmacological properties and abuse potential of 4′-F-PCP have not been fully characterized. In this study, we evaluated the psychomotor, rewarding, and reinforcing properties of 4′-F-PCP using the open-field test, conditioned place preference (CPP), and self-administration paradigms in rodents. Using Western immunoblotting, we also investigated the expression of dopamine (DA)-related proteins and DA-receptor-mediated downstream signaling cascades in the nucleus accumbens (NAc) of 4′-F-PCP-self-administering rats. Intraperitoneal administration of 10 mg/kg 4′-F-PCP significantly increased locomotor and rearing activities and increased CPP in mice. Intravenous administration of 1.0 mg/kg/infusion of 4′-F-PCP significantly enhanced self-administration during a 2 h session under fixed ratio schedules, showed a higher breakpoint during a 6 h session under progressive ratio schedules of reinforcement, and significantly altered the expression of DA transporter and DA D1 receptor in the NAc of rats self-administering 1.0 mg/kg 4′-F-PCP. Additionally, the expression of phosphorylated (p) ERK, pCREB, c-Fos, and FosB/ΔFosB in the NAc was significantly enhanced by 1.0 mg/kg 4′-F-PCP self-administration. Taken together, these findings suggest that 4′-F-PCP has a high potential for abuse, given its robust psychomotor, rewarding, and reinforcing properties via activation of DAergic neurotransmission and the downstream signaling pathways in the NAc. Full article
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Review

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Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain
Int. J. Mol. Sci. 2020, 21(6), 2023; https://doi.org/10.3390/ijms21062023 - 16 Mar 2020
Abstract
Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and [...] Read more.
Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal regeneration, energy homeostasis, autophagy, and amino acid uptake. In addition, Rheb–mTORC1 signaling plays a crucial role in preventing the neurodegeneration of hippocampal neurons in the adult brain. Increasing evidence suggests that the constitutive activation of Rheb has beneficial effects against neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Our recent studies revealed that adeno-associated virus serotype 1 (AAV1) transduction with Rheb(S16H), a constitutively active form of Rheb, exhibits neuroprotective properties through the induction of various neurotrophic factors, promoting neurotrophic interactions between neurons and astrocytes in the hippocampus of the adult brain. This review provides compelling evidence for the therapeutic potential of AAV1–Rheb(S16H) transduction in the hippocampus of the adult brain by exploring its neuroprotective effects and mechanisms. Full article
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