Nutrient Sensing in Human Metabolic Diseases: Associated Molecular Mechanisms

Dear Colleagues,

One of the research areas in which modern food and nutrition sciences intersect with molecular biology is nutritional genomics, which creates a wide range opportunities to study the relationship between the genome, nutrition, and health.

Studying the impact of bioactive diet ingredients on gene expression, the relationship between diet and genetic predisposition to civilisation diseases (metabolic, cardiovascular, cancer), identification of single-nucleotide polymorphisms and alleles responsible for a differentiated response or reactions of the body to bioactive ingredients of the diet, and finally designing and recommending diets appropriate for specific individuals or populations are just some of the interests of research in nutrigenomics and nutrigenetics.

In the post-genomics era, the rapid development of molecular biology has created new research opportunities that are now full of potential and interdisciplinary character. They require the use of bioinformatics, statistical analyses and "omics" research technologies. Their area includes research on genome stability (DNA damage at the level of single genes and entire chromosomes) and epigenetic variability (e.g. DNA methylation). It can also be extended to analyse the transcriptome (including miRNA and siRNA), proteome, metabolome or microbiome. These research areas can be analyzed independently or in an integrated way, giving the opportunity to study complex interactions (systems biology). The technological developments continue, especially with regards to DNA and RNA sequencing, mass spectrometry, single-cell omics and bioinformatics.

We ask you to please join this important discussion by submitting research papers, communications and review articles on a chosen aspect of this broad topic to the special issue of the International Journal of Molecular Sciences entitled „Nutrient Sensing in Human Metabolic Diseases - Associated Molecular Mechanisms”.

Dr. Wioletta Dudzińska
Dr. Lidia Skuza
Guest Editors

Manuscript Submission Information

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• nutrition
• functional food
• bioactive compounds
• gene
• nutrigenomics
• nutrigenetics
• metabolomics
• proteomics
• microbiota
• chronic diseases