Pathogenic Mechanisms of Muscle Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 2750
Special Issue Editors
Interests: idiopathic inflammatory myopathies; sporadic inclusion body myositis (sIBM); protein aggregates myopathies; nuclear envelopathies; amyotrophic lateral sclerosis
Special Issues, Collections and Topics in MDPI journals
Interests: skeletal muscle diseases; immune and hematopoietic systems; nuclear pore complex
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Muscle diseases comprise a heterogeneous group of inherited or acquired conditions that affect the muscular system. Although individually rare, these disorders collectively afflict millions of people worldwide. The cardinal clinical feature is weakness that is usually progressive and involves mainly proximal muscles, but the distribution of muscular impairment and its severity may vary widely. Although significant progress has been made in the identification of causative genes and mutations, the pathogenesis and basic mechanisms of several of muscle diseases remain to be fully elucidated. Muscle biopsy from patients, primary human skeletal muscle tissue cultures, and disease modeling in different organisms have turned out to be powerful and valuable tools to dissect the complex pathophysiology of such diseases, with the ultimate goal of developing novel therapeutic targets.
This Special Issue will focus on studies exploring the cellular and molecular mechanisms underpinning primary muscle diseases, both genetic and acquired, by using in vitro and in vivo experimental models as well as patient-derived material. Original research articles, mini and full reviews, short communications, perspectives, and commentaries are welcome.
Dr. Gaetano Vattemi
Dr. Valeria Guglielmi
Guest Editors
Manuscript Submission Information
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Keywords
- acquired muscle diseases
- inherited muscle diseases
- pathogenesis
- molecular and cellular mechanisms
- in vitro and in vivo models
