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State-of-the-Art Molecular Toxicology in Korea
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State-of-the-Art Molecular Toxicology in Korea

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2049

Special Issue Editor

Prof. Dr. Ju-Tae Sohn

E-Mail Website
Collection Editor
Department of Anesthesiology and Pain Medicine, College of Medicine, Gyeongsang National University (GSNU), Jinju-si 52727, Republic of Korea
Interests: anesthetics; vascular pharmacology; lipid emulsion; local anesthetic toxicity; calcium; nitric oxide; smooth muscle contraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Topical Collection aims to provide a comprehensive overview of state-of-the-art of Molecular Toxicology in Korea. We invite research papers that will consolidate our understanding in this area. The Topical Collection will publish full research articles and comprehensive reviews. Potential topics include but are not limited to the following research areas:

  • Food, drug and chemical toxicology
  • Genetic toxicology
  • Reproductive toxicology
  • Neurotoxicology
  • Nanotoxicology
  • Environmental toxicology and ecotoxicology
  • Computational and predictive toxicology
  • Food-drug interactions
  • Idiosyncratic toxicity
  • Toxins
  • Lipid emulsion resuscitation

Prof. Dr. Ju-Tae Sohn
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food, drug and chemical toxicology
  • genetic toxicology
  • reproductive toxicology
  • neurotoxicology
  • nanotoxicology
  • environmental toxicology and ecotoxicology
  • computational and predictive toxicology
  • food-drug interactions
  • idiosyncratic toxicity
  • toxins
  • lipid emulsion resuscitation

Published Papers (1 paper)

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Research

19 pages, 4771 KiB  
Article
Pulmonary Toxicity and Proteomic Analysis in Bronchoalveolar Lavage Fluids and Lungs of Rats Exposed to Copper Oxide Nanoparticles
by Jung-Taek Kwon, Yoonjin Kim, Seonyoung Choi, Byung-ll Yoon, Hyun-Sook Kim, Ilseob Shim and Donggeun Sul
Int. J. Mol. Sci. 2022, 23(21), 13265; https://doi.org/10.3390/ijms232113265 - 31 Oct 2022
Cited by 10 | Viewed by 1770
Abstract
Copper oxide nanoparticles (CuO NPs) were intratracheally instilled into lungs at concentrations of 0, 0.15, and 1.5 mg/kg bodyweight to 7-week-old Sprague–Dawley rats. The cytotoxicity, immunotoxicity, and oxidative stress were evaluated, followed by proteomic analysis of bronchoalveolar lavage fluid (BALF) and lungs of [...] Read more.
Copper oxide nanoparticles (CuO NPs) were intratracheally instilled into lungs at concentrations of 0, 0.15, and 1.5 mg/kg bodyweight to 7-week-old Sprague–Dawley rats. The cytotoxicity, immunotoxicity, and oxidative stress were evaluated, followed by proteomic analysis of bronchoalveolar lavage fluid (BALF) and lungs of rats. The CuO NPs-exposed groups revealed dose-dependent increases in total cells, polymorphonuclear leukocytes, lactate dyhydrogenase, and total protein levels in BALF. Inflammatory cytokines, including macrophage inflammatory protein-2 and tumor necrosis factor-α, were increased in the CuO NPs-treated groups. The expression levels of catalase, glutathione peroxidase-1, and peroxiredoxin-2 were downregulated, whereas that of superoxide dismutase-2 was upregulated in the CuO NPs-exposed groups. Five heat shock proteins were downregulated in rats exposed to high concentrations of CuO NPs. In proteomic analysis, 17 proteins were upregulated or downregulated, and 6 proteins were validated via Western blot analysis. Significant upregulation of 3-hydroxy-3-methylglutaryl-CoA synthase and fidgetin-like 1 and downregulation of annexin II, HSP 47 and proteasome α1 occurred in the CuO NPs exposed groups. Taken together, this study provides additional insight into pulmonary cytotoxicity and immunotoxicity as well as oxidative stress in rats exposed to CuO NPs. Proteomic analysis revealed potential toxicological biomarkers of CuO NPs, which also reveals the toxicity mechanisms of CuO NPs. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Toxicology in Korea)
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