Mitochondrial Dysfunction in Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (10 June 2024) | Viewed by 15809
Special Issue Editors
Interests: neurological diseases; pathophysiology; therapeutics; animal models; molecular mechanisms; drug development; mitochondria; biomarker; posttranslational modification; transcription factor; gut-brain axis; Huntington’s disease; Parkinson’s disease; Alzheimer’s disease
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Special Issue Information
Dear Colleagues,
Mitochondria, as the tiny cellular organelles that serve as both guardians as well as the executioners of a variety of cellular functions essential for cell survival, have rightly claimed their place in the forefront of investigations relating to neurodegeneration. Alterations in mitochondrial bioenergetics, dynamics (fission–fusion, movement), mitophagy and oxidative stress originating at mitochondria have long been intertwined as causative factors for neurodegenerative diseases. Neurodegeneration itself is a very complex process, and the various factors involved in its aetiology are not yet fully understood, which is why there are no disease-modifying therapies available. However, the future is not bleak; with recent technological advances, it is now possible to probe further than ever before into the mitochondria-related mechanisms of neurodegeneration. New factors, interactions and processes are being discovered every day. We are poised to make great strides towards finding a cure and, with our Special Issue, we hope to take advantage of this crucial turning point. We intend to provoke a healthy and fruitful discussion on mitochondria-targeted therapies in development and bring to the fore new and current advances in the understanding and clinical development of some of these disease mechanisms, biomarkers and therapies.
Dr. Ashu Johri
Dr. Abhishek Chandra
Guest Editors
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Keywords
- neurodegeneration
- mitochondria
- biomarker
- therapeutics
- clinical development
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