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Metabolomic Profiling in Prenatal Health Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 372

Special Issue Editor


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Guest Editor
Corewell Health William Beaumont University Hospital, Royal Oak, MI 48073, USA
Interests: obstetrics; biomarkers; metabolomics; epigenomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the past decade, metabolomics science has become a powerful analytical tool for elucidating disease pathogenesis. Furthermore, it has led to the discovery of early and accurate biomarkers for many human diseases. These advancements have earned metabolomics science the title of the “stethoscope for the 21st century”. Pregnant women are at significant risk of morbidity and mortality, which has a significant impact on fetal health. Additionally, pregnancy disorders are characterized by enormous pathogenic complexity, which makes them ideally suited for metabolomic interrogation. The deployment of metabolomic tools to address the challenges in diagnosing common disorders such as premature cervical shortening, fetal growth restriction, miscarriage, ectopic pregnancy, prematurity, preeclampsia, gestational diabetes, and fetal congenital anomalies is warranted.

In this Special Issue, titled “Metabolomic Profiling in Prenatal Health Research”, the International Journal of Molecular Sciences issues a call for contributions that use metabolomic approaches to probe and answer pressing questions in prenatal medicine. Reviews and perspectives as well as original research studies are welcome. We hope that this Special Issue will build on preexisting pioneering work in this consequential scientific area, and serve to heighten interest and energize both new and established researchers working in the fields of obstetrics and metabolomics.

Dr. Onur Turkoglu
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolomics
  • biomarker
  • obstetrics
  • prenatal health
  • maternal health
  • fetal health
  • perinatology
  • high risk
  • pregnancy

Published Papers (1 paper)

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Research

10 pages, 648 KiB  
Article
The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach
by Enrico Valerio, Marta Meneghelli, Matteo Stocchero, Alfonso Galderisi, Silvia Visentin, Luca Bonadies, Paola Pirillo, Gabriele Poloniato, Giuseppe Giordano and Eugenio Baraldi
Int. J. Mol. Sci. 2024, 25(11), 5860; https://doi.org/10.3390/ijms25115860 - 28 May 2024
Viewed by 264
Abstract
We analyzed and compared variations in the urinary metabolome, as well as postnatal clinical outcomes among preterm infants, based on the timing of antenatal corticosteroid (ACS) administration in response to preterm labor onset in their mothers. This was a prospective observational study held [...] Read more.
We analyzed and compared variations in the urinary metabolome, as well as postnatal clinical outcomes among preterm infants, based on the timing of antenatal corticosteroid (ACS) administration in response to preterm labor onset in their mothers. This was a prospective observational study held in the Neonatal Intensive Care Unit, Department of Woman’s and Child’s Health, Padova University Hospital (Italy). A urine sample was obtained from each patient within 24 h of birth; Mass Spectrometry-based untargeted metabolomics analysis was then conducted. We searched for any significant disparities in the metabolomic profile of preterm newborns subjected to antenatal corticosteroid (ACS) treatment at varying timings; their correlation with clinical outcomes were also evaluated. The group receiving ACS within the optimal time window (1–7 days before delivery) exhibited elevated levels of cysteine, N-acetylglutamine, propionyl carnitine and 5-hydroxyindolacetic acid, coupled with a decrease in pipecolic acid. Clinically, this group demonstrated a reduced need for invasive ventilation (p = 0.04). In conclusion, metabolomics analysis identified several metabolites that discriminated preterm infants whose mothers received ACS within the recommended time window. Elevated levels of cysteine and 5-Hydroxyindoleacetic acid, metabolites characterized by antioxidant and anti-inflammatory properties, were observed in these infants. This metabolic profile correlated with improved respiratory outcomes, as evidenced by a reduced necessity for invasive ventilation at birth. Full article
(This article belongs to the Special Issue Metabolomic Profiling in Prenatal Health Research)
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