Targeting Epigenetics in Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (25 July 2024) | Viewed by 4450
Special Issue Editor
Interests: DNA methylation; histone acetylation; DNMT inhibitors; hematologic malignancies; acute myeloid leukemia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the foundational role of chemotherapy in cancer treatment, epigenetic therapy also has a significant impact as a monotherapy or combined therapy. Epigenetic therapy relies on the reversible nature of epigenetic modifications, which establish dynamic shifts between active and suppressed transcriptional states. A myriad of enzymes are involved in establishing the dynamic epigenetic changes and each could represent a potential target in cancer treatment. Currently, histone deacetylase (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors are approved for use in specific hematologic malignancies.
In this Special Issue, we aim to identify novel epigenetic targets and epigenetic modifiers that could have potential in cancer therapeutics. We are also interested in understanding the molecular basis of existing epigenetic therapies and the expansion of their clinical utility in different types of cancer. Finally, the role of herbal medicine in reversing epigenetic changes, with the consequent induction of tumor arrest and apoptosis of cancer cells, is also an aim of this Special Issue. It is worth mentioning that pure clinical studies will not be suitable for submission in this issue and only clinical or pure model submissions with biomolecular experiments are welcome.
Dr. Tamer E. Fandy
Guest Editor
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Keywords
- epigenetic therapy
- histone acetylation
- histone modifications
- DNA methylation
- DNA methyltransferase inhibitors
- histone deacetylase inhibitors
- histone methylation
- miRNA modifications
- herbal products
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