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Research Progress of Tumor Endothelial Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 671

Special Issue Editor

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Guest Editor
Institute for Molecular Medicine (IMM), MSH Medical School Hamburg, 20457 Hamburg, Germany
Interests: hereditary vascular diseases; neurovascular biology; hereditary cancer syndromes; clinical genetics; molecular diagnostics

Special Issue Information

Dear Colleagues,

The complex interplay of tumor cells and stromal cells of the tumor microenvironment significantly impacts abnormal proliferation, invasion, metastasis, and other hallmarks of cancer. Single-cell RNA sequencing analyses have provided fascinating new insights into the cellular composition of the tumor microenvironment in recent years.

Tumor endothelial cells (TECs), which differ significantly from normal endothelial cells at the genetic, molecular, metabolic, and functional levels, can support tumor progression and metastasis, for example, by promoting angiogenesis or modulating the anticancer immune response. Due to their important role in the tumor microenvironment, TECs have been identified as promising targets for cancer therapy. In addition to anti-angiogenic treatments, immunomodulatory approaches are increasingly focusing on TECs. However, in addition to new insights into the origin and characteristics of TECs, we have recently learned a lot about the inter- and intratumoral heterogeneity of TECs, which may influence the efficacy of cancer therapies.

This Special Issue of the International Journal of Molecular Sciences, entitled “Research Progress of Tumor Endothelial Cells”, focuses on a better understanding of the molecular, functional, and metabolic characteristics of TECs, their role in the tumor microenvironment and novel targets for cancer therapy. We welcome both original research articles and up-to-date review papers from fundamental, clinical, and translational research.

Prof. Dr. Matthias Rath
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • tumorigenesis
  • cancer
  • metastasis
  • endothelial cells (ECs)
  • tumor cells
  • tumor microenvironment
  • metabolism
  • proliferation
  • invasion
  • vascular
  • microvascular
  • tumor angiogenesis
  • sprouting

Published Papers (1 paper)

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21 pages, 6875 KiB  
Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma
by Cinzia Cocola, Edoardo Abeni, Valentina Martino, Eleonora Piscitelli, Paride Pelucchi, Ettore Mosca, Alice Chiodi, Tasnim Mohamed, Mira Palizban, Giovanni Porta, Helga Palizban, Giovanni Nano, Francesco Acquati, Antonino Bruno, Burkhard Greve, Daniela Gerovska, Valerio Magnaghi, Daniela Mazzaccaro, Giovanni Bertalot, James Kehler, Cristiana Balbino, Marcos J. Arauzo-Bravo, Martin Götte, Ileana Zucchi and Rolland A. Reinboldadd Show full author list remove Hide full author list
Int. J. Mol. Sci. 2024, 25(7), 3967; https://doi.org/10.3390/ijms25073967 - 03 Apr 2024
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High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that promote both destructive tissue remodeling and aberrant vascularization of the brain. The formation of defective and permeable blood vessels and microchannels and destructive tissue [...] Read more.
High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that promote both destructive tissue remodeling and aberrant vascularization of the brain. The formation of defective and permeable blood vessels and microchannels and destructive tissue remodeling prevent efficient vascular delivery of pharmacological agents to tumor cells and are the significant reason why therapeutic chemotherapy and immunotherapy intervention are primarily ineffective. Vessel-forming endothelial cells and microchannel-forming glial cells that recapitulate vascular mimicry have both infiltration and destructive remodeling tissue capacities. The transmembrane protein TMEM230 (C20orf30) is a master regulator of infiltration, sprouting of endothelial cells, and microchannel formation of glial and phagocytic cells. A high level of TMEM230 expression was identified in patients with HGG, GBM, and U87-MG cells. In this study, we identified candidate genes and molecular pathways that support that aberrantly elevated levels of TMEM230 play an important role in regulating genes associated with the initial stages of cell infiltration and blood vessel and microchannel (also referred to as tumor microtubule) formation in the progression from low-grade to high-grade gliomas. As TMEM230 regulates infiltration, vascularization, and tissue destruction capacities of diverse cell types in the brain, TMEM230 is a promising cancer target for heterogeneous HGG tumors. Full article
(This article belongs to the Special Issue Research Progress of Tumor Endothelial Cells)
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