Advanced Research of tRNA
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 6427
Special Issue Editor
Interests: therapeutic nucleic acids; siRNAs; antisense oligonucleotides; CRISPR/Cas9 gene editing; tRNA; epitranscriptomics; nucleoside modifications; nucleoside modifying enzymes; genetic code decoding; codon-anticodon interaction; oxidative tRNA damage; biotechnology and recombinant proteins
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Special Issue Information
Dear Colleagues,
The second half of the 19th and the 20th centuries were marked by great discoveries in the field of nucleic acids, which ushered in a new era in the development of biological sciences. The discovery of nucleic acids, the determination of their functions and structures, the deciphering of the genetic code, the identification of the first modified nucleosides in RNA, and much more have laid the foundation for modern molecular biology.
One of these great achievements was the discovery of transfer ribonucleic acid (tRNA). Exactly 65 years ago, in 1958, Mahlon B. Hoagland and Paul C. Zamecnik informed the scientific community of the discovery of an endogenous low-molecular-weight RNA fraction that acts as an intermediate in the movement of amino acids from the ATP-activated state to the newly formed protein. Confirmation of the presence of an adapter molecule that serves as a physical link between the genetic information and an amino acid sequence of a growing polypeptide chain was an excellent explanation for the flow of genetic information in biological systems.
On the occasion of the anniversary of tRNA, we would like to commemorate its history, but more importantly, highlight the great progress that has been made in the study of the structure, function, and chemical modifications of nucleosides in tRNA. This Special Issue of the International Journal of Molecular Sciences focuses on advanced research in the field of tRNA, particularly tRNA biology, the development of new modifications and their effects on tRNA functions, tRNA-modifying enzymes, the effects of stress conditions on the presence or absence of nucleoside modifications in tRNA, and tRNA damage and its impact on cellular health or disease. We invite and encourage scientists to submit original research manuscripts or review articles discussing the latest aspects of tRNA research. We hope to provide a useful compilation of the latest developments in tRNA biology.
Dr. Małgorzata Sierant
Guest Editor
Manuscript Submission Information
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Keywords
- transfer ribonucleic acid, tRNA
- tRNA structure
- tRNA maturation
- tRNA modification
- epitranscriptomics
- tRNA function
- codon–anticodon recognition
- translation
- decoding the genetic code
- tRNA damages
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