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New Insight into Cannabinoid Effects 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 721

Special Issue Editor

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Guest Editor
Division of Gastroenterology and Hepatology, Meir Medical Center, Affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv 5265601, Israel
Interests: endocannabinoid; inflammatory bowel disease; cannabis use in IBD; cannabis
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Special Issue Information

Dear Colleagues,

Cannabis is the most widely used recreational drug worldwide.  The cannabis plant contains as many as 100 phytocannabinoids as well as other ingredients, such as terpenes and flavonoids.  Phytocannabinoids exert their effects through the endocannabinoid system (ECS), which is an endogenous system with an important role in modulating mood, memory, reward homeostasis, immune regulation, and energy balance.  The best-known phytocannabinoids are Δ9-tetrahydrocannabinol (THC), which is responsible for the psychotropic effect of cannabis, and cannabidiol (CBD), which does not have a central effect but is shown to have an anti-inflammatory effect.

The use of medical cannabis is rapidly increasing, and physicians are faced with an increasing demand from patients to prescribe it.  Sadly, this is not accompanied by scientifically sound evidence regarding the efficacy, if any, of cannabis treatment.  Very little is known about the effect of cannabis and the significance of various cannabinoid combinations or mode of cannabis consumption.  On the other hand, we cannot afford to ignore the many reports about the positive effects of cannabis.  More data and evidence on how cannabinoids affect physiology and pathophysiology, as well as their therapeutic potential are urgently needed.
The open access International Journal of Molecular Sciences (IJMS) (IF 6.208, ISSN 1422-0067) is therefore planning this Special Issue entitled “New Insight into Cannabinoid Effects 3.0”.  As the Guest Editor, I would like to invite you to contribute an article/review to this issue.  We promise you a rapid and rigorous peer review, manuscript handling, and editorial process.

Dr. Timna Naftali
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cannabinoids
  • endogenous cannabinoids
  • neurodegenerative diseases
  • cancer
  • pharmacology

Published Papers (1 paper)

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16 pages, 3041 KiB  
Timeframe Analysis of Novel Synthetic Cannabinoids Effects: A Study on Behavioral Response and Endogenous Cannabinoids Disruption
by Jorge Carlos Pineda Garcia, Ren-Shi Li, Ruri Kikura-Hanajiri, Yoshitaka Tanaka and Yuji Ishii
Int. J. Mol. Sci. 2024, 25(6), 3083; https://doi.org/10.3390/ijms25063083 - 07 Mar 2024
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This study investigates the impact of SCs consumption by assessing the effects of three novel synthetic cannabinoids (SCs); MDMB-CHMINACA, 5F-ADB-PINACA, and APICA post-drug treatment. SCs are known for their rapid onset (<1 min) and prolonged duration (≥5 h). Therefore, this research aimed to [...] Read more.
This study investigates the impact of SCs consumption by assessing the effects of three novel synthetic cannabinoids (SCs); MDMB-CHMINACA, 5F-ADB-PINACA, and APICA post-drug treatment. SCs are known for their rapid onset (<1 min) and prolonged duration (≥5 h). Therefore, this research aimed to assess behavioral responses and their correlation with endocannabinoids (ECs) accumulation in the hippocampus, and EC’s metabolic enzymes alteration at different timeframes (1-3-5-h) following drug administration. Different extents of locomotive disruption and sustained anxiety-like symptoms were observed throughout all-encompassing timeframes of drug administration. Notably, MDMB-CHMINACA induced significant memory impairment at 1 and 3 h. Elevated levels of anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) were detected 1 h post-MDMB-CHMINACA and 5F-ADB-PINACA administration. Reduced mRNA expression levels of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) (AEA and 2-AG degrading enzymes, respectively), and brain-derived neurotrophic factor (BDNF) occurred at 1 h, with FAAH levels remaining reduced at 3 h. These findings suggest a connection between increased EC content and decreased BDNF expression following SC exposure. Cognitive disruption, particularly motor coordination decline and progressive loss manifested in a time-dependent manner across all the analyzed SCs. Our study highlights the importance of adopting a temporal framework when assessing the effects of SCs. Full article
(This article belongs to the Special Issue New Insight into Cannabinoid Effects 3.0)
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