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The Role of Cellular Ion Channels and Transporters in Cancers
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The Role of Cellular Ion Channels and Transporters in Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 9355

Special Issue Editors

Dr. Maxime Guéguinou

E-Mail Website
Guest Editor
Inserm UMR 1069, Nutrition Croissance Cancer, Faculté de Médecine, Université de Tours, F-37032 Tours, France
Interests: ion channels; calcium signaling; mitochondria; cancer cells
Dr. David Crottès

E-Mail Website
Guest Editor
Inserm UMR 1069, Nutrition Croissance Cancer, Faculté de Médecine, Université de Tours, F-37032 Tours, France
Interests: ion channel; microenvironnement; calcium homeostasis; cancer cells

Special Issue Information

Dear Colleagues, 

A growing literature demonstrate the important roles of ion channels and transporters in cancer and their interest as new therapeutic targets and biomarkers. Initially observed in cancer cell proliferation, the role of ion channels and transporters in cancer cells has rapidly spread to all hallmarks of cancer including interactions of cancer cells with their micro-environment and the development of cancer resistance to therapy.

The aim of this Special Issue will be to provide latest progress and current understanding of the contribution of ion channels in multiple aspects of cancers and to highlight their potential as new therapeutic targets of the tumour itself or the tumor micro-environment.

The scope of this Special Issue will include all ion channels and transporters (expressed at the plasma membrane or intracellular organelles) and their contribution in any aspects of tumorigenesis including but not limited to the biology of cancer cells (migration, proliferation, invasion, energetic metabolism, apoptosis resistance, …), the tumor micro-environment (stroma, vascular, immune compartments) or the cancer resistance to therapy. Special interest will be given to articles discussing the non-canonical functions of ion channels in cancers. Original research articles and review will be considerate.

Dr. Maxime Guéguinou
Dr. David Crottès
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer cells
  • immunity cells
  • ion channels
  • intracellular organelles
  • signalling pathways
  • pharmacology

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Published Papers (2 papers)

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Review

19 pages, 1452 KiB  
Review
Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
by Álvaro Otero-Sobrino, Pablo Blanco-Carlón, Miguel Ángel Navarro-Aguadero, Miguel Gallardo, Joaquín Martínez-López and María Velasco-Estévez
Int. J. Mol. Sci. 2023, 24(18), 13710; https://doi.org/10.3390/ijms241813710 - 5 Sep 2023
Cited by 14 | Viewed by 3449
Abstract
Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to [...] Read more.
Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have an important role in regulating proliferation, cell fate and differentiation, migration and cellular stress, among other processes. Indeed, the mechanical properties of the extracellular matrix in cancer change drastically due to high cell proliferation and modification of extracellular protein secretion, suggesting an important contribution to tumor cell regulation. In this review, we describe the physiological significance of mechanosensitive ion channels, emphasizing their role in cancer and immunity, and providing compelling proof of the importance of continuing to explore their potential as new therapeutic targets in cancer research. Full article
(This article belongs to the Special Issue The Role of Cellular Ion Channels and Transporters in Cancers)
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49 pages, 4181 KiB  
Review
Ion Channels in Gliomas—From Molecular Basis to Treatment
by Abdallah F. Elias, Bernice C. Lin and Beverly J. Piggott
Int. J. Mol. Sci. 2023, 24(3), 2530; https://doi.org/10.3390/ijms24032530 - 28 Jan 2023
Cited by 11 | Viewed by 5172
Abstract
Ion channels provide the basis for the nervous system’s intrinsic electrical activity. Neuronal excitability is a characteristic property of neurons and is critical for all functions of the nervous system. Glia cells fulfill essential supportive roles, but unlike neurons, they also retain the [...] Read more.
Ion channels provide the basis for the nervous system’s intrinsic electrical activity. Neuronal excitability is a characteristic property of neurons and is critical for all functions of the nervous system. Glia cells fulfill essential supportive roles, but unlike neurons, they also retain the ability to divide. This can lead to uncontrolled growth and the formation of gliomas. Ion channels are involved in the unique biology of gliomas pertaining to peritumoral pathology and seizures, diffuse invasion, and treatment resistance. The emerging picture shows ion channels in the brain at the crossroads of neurophysiology and fundamental pathophysiological processes of specific cancer behaviors as reflected by uncontrolled proliferation, infiltration, resistance to apoptosis, metabolism, and angiogenesis. Ion channels are highly druggable, making them an enticing therapeutic target. Targeting ion channels in difficult-to-treat brain tumors such as gliomas requires an understanding of their extremely heterogenous tumor microenvironment and highly diverse molecular profiles, both representing major causes of recurrence and treatment resistance. In this review, we survey the current knowledge on ion channels with oncogenic behavior within the heterogeneous group of gliomas, review ion channel gene expression as genomic biomarkers for glioma prognosis and provide an update on therapeutic perspectives for repurposed and novel ion channel inhibitors and electrotherapy. Full article
(This article belongs to the Special Issue The Role of Cellular Ion Channels and Transporters in Cancers)
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