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The Immunobiology of Cannabinoids in Health and Diseases
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The Immunobiology of Cannabinoids in Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 November 2022)

Special Issue Editor

Prof. Dr. Babak Baban

E-Mail Website
Guest Editor
Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA
Interests: innate immunity; inflammation; neuroinflammation; immune regulation; microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Increasing evidence support the notion that Cannabinoids have the potential to alter the immune system. Considering the significance of immune system in human health and survival, it is then conceivable to explore the effects of Cannabinoids on the immune system and its possible potency to be targeted as an immune-modulatory agent in the treatment of diseases and specifically inflammatory disorders. Importantly, despite all advances in the development of synthetic immune regulators, there is still an exigent need for alternative and safer interventional modalities to treat diseases and pathologic conditions. Plant-based compounds could be highly preferable due to their natural and organic features and their availability.  While there are extensive ongoing studies on the medicinal effects of cannabis and cannabinoids, it is still largely unknown how cannabis and cannabinoids exert their therapeutic effects. Furthermore, the exact mechanisms of the endocannabinoid system and its relationship with cannabis and phytocannabinoids are still obscure.

This Special Issue is consecrated to unraveling the dynamics and Immunobiology of cannabis as well as better understanding of interactive mechanisms responsible for the cross-talk between cannabis/endocannabinoid setting and the immune system. We will focus on basic and translational research and studies on the Immunobiologic features of cannabinoids and endocannabinoid system through an immunologic paradigm. The ultimate goal would be to benefit of both academia and industry. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

  • Medicinal cannabis and inflammatory responses
  • Medicinal cannabis and age-related diseases
  • Medicinal cannabis and malignancies
  • Medicinal cannabis and cognitive function
  • Medicinal cannabis and metabolic diseases
  • Medicinal cannabis and psychiatric diseases

Prof. Dr. Babak Baban
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cannabinoids
  • immunobiology
  • inflammation

Published Papers (1 paper)

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Research

15 pages, 1810 KiB  
Article
Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits
by Andrea Termine, Carlo Fabrizio, Juliette Gimenez, Anna Panuccio, Francesca Balsamo, Noemi Passarello, Silvia Caioli, Luana Saba, Marco De Bardi, Francesco Della Valle, Valerio Orlando, Laura Petrosini and Daniela Laricchiuta
Int. J. Mol. Sci. 2022, 23(5), 2538; https://doi.org/10.3390/ijms23052538 - 25 Feb 2022
Cited by 1 | Viewed by 1825
Abstract
Approach and avoidance (A/A) tendencies are stable behavioral traits in responding to rewarding and fearful stimuli. They represent the superordinate division of emotion, and individual differences in such traits are associated with disease susceptibility. The neural circuitry underlying A/A traits is retained to [...] Read more.
Approach and avoidance (A/A) tendencies are stable behavioral traits in responding to rewarding and fearful stimuli. They represent the superordinate division of emotion, and individual differences in such traits are associated with disease susceptibility. The neural circuitry underlying A/A traits is retained to be the cortico-limbic pathway including the amygdala, the central hub for the emotional processing. Furthermore, A/A-specific individual differences are associated with the activity of the endocannabinoid system (ECS) and especially of CB1 receptors whose density and functionality in amygdala differ according to A/A traits. ECS markedly interacts with the immune system (IS). However, how the interplay between ECS and IS is associated with A/A individual differences is still ill-defined. To fill this gap, here we analyzed the interaction between the gene expression of ECS and immune system (IS) in relation to individual differences. To unveil the deep architecture of ECS-IS interaction, we performed cell-specific transcriptomics analysis. Differential gene expression profiling, functional enrichment, and protein–protein interaction network analyses were performed in amygdala pyramidal neurons of mice showing different A/A behavioral tendencies. Several altered pro-inflammatory pathways were identified as associated with individual differences in A/A traits, indicating the chronic activation of the adaptive immune response sustained by the interplay between endocannabinoids and the IS. Furthermore, results showed that the interaction between the two systems modulates synaptic plasticity and neuronal metabolism in individual difference-specific manner. Deepening our knowledge about ECS/IS interaction may provide useful targets for treatment and prevention of psychopathology associated with A/A traits. Full article
(This article belongs to the Special Issue The Immunobiology of Cannabinoids in Health and Diseases)
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