Phytochemicals as Natural Nutrients in the Prevention and Therapy of Diseases

Dear Colleagues,

For this Special Issue, we invite original research and reviews that explore the broad range of multidisciplinary roles of phytochemicals in disease prevention and therapy. It is with great pleasure that we extend a cordial invitation to researchers, scientists, and clinicians to contribute to this Special Issue, which presents a unique opportunity to share novel findings and practical applications linked to the roles of phytochemicals in the prevention and treatment of disease. Contributions in the form of original research, reviews, or case studies are welcome so long as they contribute to the advancement of knowledge regarding the integration of plant-derived bioactives into contemporary healthcare strategies.

This Special Issue will explore the vast and multidisciplinary potential of phytochemicals for use in the prevention and treatment of diseases. While our focus includes key areas such as molecular mechanisms of action, dietary sources of phytonutrients, bioavailability enhancement strategies, clinical applications of antioxidants, and synergistic effects of phytochemicals, our scope is not limited to these topics. Contributions that expand our understanding of phytochemicals' interactions with gut microbiota modulation, epigenetic regulation pathways, innovative delivery systems, lifestyle integration strategies, functional food development, phytochemical–drug synergy, novel therapeutic applications, and sustainable approaches to dietary interventions are also highly encouraged. This Special Issue will provide a platform for advancing the application of phytochemicals in health management and therapy, addressing both foundational science and real-world implementation.

This Special Issue will explore how natural antioxidants, plant-derived bioactives, and functional nutrients contribute to both disease prevention and innovative therapeutic approaches, integrating insights from molecular biology, nutrition science, and clinical practice. By focusing on applied aspects, this Special Issue will provide practical insights into the use of phytochemicals in real-world health solutions, promoting their integration into clinical settings, dietary practices, and public health strategies.

The broad scope of this Special Issue will ensure the inclusion of diverse and emerging perspectives to enhance our understanding of the complex roles of phytochemicals in health and disease.

This Special Issue was conceived with the aim of exploring the multifaceted roles of phytochemicals in health promotion and disease management. In this context, an emphasis will be placed not only on the diverse mechanisms behind these natural compounds but also on their innovative applications.

The following key themes have been identified for this Special Issue:

1. Molecular mechanisms of phytochemicals in preventing oxidative stress and modulating inflammatory pathways;
2. Dietary sources and bioavailability strategies for enhancing the absorption and efficacy of phytonutrients, including novel delivery systems and dietary combinations;
3. Lifestyle integration, focusing on the synergy between diet, physical activity, and environmental factors in maximising the therapeutic potential of phytochemicals;
4. The clinical application of phytonutrients as adjunct therapies in the management of chronic diseases, with an emphasis on personalised nutrition and evidence from clinical trials;
5. Synergistic effects among different phytochemicals and their interactions with the gut microbiota, emphasising their role in systemic health.

The overarching objective of this Special Issue is twofold: firstly, to establish an open and inclusive thematic framework to capture groundbreaking insights into the role of phytochemicals in health and secondly, to foster innovative solutions for effectively integrating phytochemicals into both preventive and therapeutic health strategies.

The broad scope of this Special Issue is designed to encourage innovative and interdisciplinary approaches, emphasising the critical role of phytochemicals in promoting health and advancing therapeutic strategies. This Special Issue will combine perspectives from molecular biology, nutrition science, pharmacology, and clinical practice, with the aim of promoting practical, evidence-based applications of phytochemicals in real-world healthcare solutions. Our central objective in launching this Special Issue is to facilitate a dynamic interplay between scientific discovery and the development of practical health interventions, with the overarching goal of generating impactful strategies for the prevention, management, and treatment of disease.

By participating, researchers will contribute to a growing interdisciplinary effort to translate phytochemical research into impactful health solutions that can improve patient outcomes and enhance public health. We invite contributions to this field that can facilitate progress in the development of phytochemical-based therapeutic interventions.

We warmly invite you to join us in this endeavour!

Prof. Dr. Natalia Kurhaluk
Dr. Halina Tkaczenko
Guest Editors

Manuscript Submission Information

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• natural antioxidant therapy
• dietary phytochemical sources
• bioavailability enhancement techniques
• clinical nutrition applications
• phytochemical synergy effects
• chronic disease prevention
• gut microbiota modulation
• epigenetic pathway regulation
• functional food innovation
• sustainable dietary practices