Special Issue "Glutamine: An Essential Non-Essential Amino Acid"
Deadline for manuscript submissions: 31 October 2020.
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Dear Colleagues,Glutamine is a non-essential amino acid that is derived from glutamate via the action of the enzyme glutamine synthetase in most cells, and is the most common amino acid found in the blood. However, it is essential that this amino acid is present in rapidly dividing cells such as cells of the immune system and tumor cells, as the ability of these cells to synthesize glutamine is limited, and it effectively becomes an essential amino acid.
Glutamine can donate its carbon and nitrogen to ensure nucleotide, amino acid, and other macromolecule biosynthesis occurs in the cell. It can also be used as a source of cellular energy. Glutamine is a gluconeogenic substrate in the kidney, and can act as a non-toxic carrier of ammonia in body fluids.
This Special Issue of the International Journal of Molecular Sciences, “Glutamine: The Essential Non-Essential Amino Acid” will focus on the role glutamine plays in normal and transformed cells, be it catabolized to supply cellular energy or anabolized for the creation of key biomolecules in the cell. Of interest is the role that glutamine plays in the regulation of gene transcription and the changes that occur in the cell when they start to rely on this amino acid to supply many of their needs. The results from these studies will help us better understand the central role that this amino acid plays in cell and organ metabolism, and how disrupting its role in tumor cell biology may give rise to new therapeutic agents.
Dr. Terrence Piva
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- amino acids
- mitochondria and TCA cycle
- nucleotide synthesis
- cell and body metabolism
- gene regulation
- cellular transport
- immune cell function
- cell proliferation
- transformed cells
- enzyme inhibition