The Molecular Mechanism of Gastrointestinal Malignancies: The Path from Genomic Alterations to Tumor Aggressiveness
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (11 June 2021) | Viewed by 3635
Special Issue Editor
Interests: prostate cancer; immunology; microenvironment; immunotherapy; histology; complexity; modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal (GI) malignancies comprise a group of cancer types, divided by primary site and clinical characteristics, but often sharing similar driving mechanisms. Better stratification and understanding the molecular events that drive these tumors is critical in order to inhibit their development, growth and metastatic spread. Accumulating genomic data provided invaluable information regarding type and frequency of genomic alterations in GI malignancies. However, the mechanistic roles of these alterations are, in most parts, not well defined.
This issue will focus on personalized approach to GI malignancies. We seek high quality manuscripts describing the role of genomic alterations in mediating tumor aggressiveness and metastases formation; the path from genomic alterations to transcriptomic and metabolomic characteristics and the road to resistance therapy.
We specifically encourage the submission of manuscripts presenting innovative approaches exploiting these data in an attempt to identify novel strategies to inhibit tumor growth and spread and overcome resistance to current therapies.
Prof. Dr. Fabio Grizzi
Guest Editor
Manuscript Submission Information
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Keywords
- Genomic alterations
- Metastases formation
- Transcriptional regulation
- Tumor metabolism
- Targeted therapy
- Acquired resistance
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