Fibroblast Growth Factor Signaling in Development and Disease

Dear Colleagues,

The fibroblast growth factor (FGF) family comprises 23 members, which have various pleiotropic biological functions, including roles in development and disease. FGFs bind to and activate one of four highly conserved transmembrane tyrosine kinases receptors (FGFRs) that induce various intracellular signaling pathways. FGFs also act in concert with heparin, heparan sulfate proteoglycans, and/or klotho to activate the FGFRs, which induce pleiotropic cellular responses.

This Issue of the International Journal of Molecular Sciences will focus on “Fibroblast Growth Factor Signaling in Development and Disease”, such as new insights into FGF signaling and how they contribute to known or novel pathways in development and different diseases. While current data shows the importance of FGFs in different physiological and pathological cellular processes, new data is emerging for the potential of inhibition or modulation of FGF signaling as targets for future therapeutical options in various disease states. Furthermore, several cofactors or mediators as well as crosstalk pathways have been shown to impact FGF signaling and submissions on these phenomena, and their contributions are welcome for this Special Issue.

Dr. Stefanie Krick
Dr. Jarrod Barnes
Guest Editors

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