Recent Molecules Research of DNA Repair and DNA Damage
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2362
Special Issue Editor
Interests: DNA and chromosomal damage; DNA repair; colorectal cancer; pancreatic cancer; cancer risk; cancer prognosis; therapy prediction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The transfer of genetic information with high fidelity and the preservation of genomic integrity are fundamental preconditions of life. Generally, there are many pathways implicated in the maintenance of genomic integrity and the prevention of its instability. Those include mainly: (i) DNA repair mechanisms, (ii) flawless DNA replication and mitosis and (iii) telomere maintenance.
On the background of abundant and versatile arising DNA damage, the complex biological system of DNA repair has evolved to ensure fidelity of the genetic information, genomic stability, and integrity of the cells. It comprises several distinct pathways repairing different types of DNA damage. Notably, some lesions serve as substrates for more than one pathway, and no single pathway repairs all types of DNA lesions. DNA repair pathways comprise BER, nucleotide excision repair (NER), mismatch repair (MMR), double-strand break repair (homologous recombination – HR and non-homologous end joining - NHEJ), and direct reversal DNA repair. Translesion synthesis (TLS) and the Fanconi anaemia (FA) pathways belong also to this system.
The DNA damage accumulation and altered DNA damage response clearly underlie several human pathologies, namely various kinds of cancer. In addition, DNA damage and DNA repair play a role in degenerative diseases as well. Furthermore, DNA damage accumulation and changes in DNA repair may occur in the physiological ageing.
This Special Issue of the International Journal of Molecular Sciences on “Recent Molecules Research of DNA Repair and DNA Damage”, supervised by Dr. Vodička Pavel (Charles University, Czech Republic) and assisted by Dr. Eylül Bankoglu (University of Wuerzburg, Germany), aims to understand DNA damage/DNA repair in humans and their potential implications to pathologies. These comprise (a) the interindividual, intersex and between age groups differences in DNA damage/DNA repair, (b) the differences in various organs (target versus firs-pass organs), (c) the role of DNA damage/DNA repair in the ethiology of proliferative versus degenerative diseases, (d) possible inducibility of DNA repair proteins and adaptive response, (e) the role of genetics and epigenetics on DNA repair.
Dr. Pavel Vodicka
Guest Editor
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Keywords
- DNA repair
- DNA damage
- human pathologies
- solid cancers
- degenerative diseases
- anticancer therapy
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