Molecular Aspects of Healthy Aging

Dear Colleagues,

Advancements in understanding the molecular processes of ageing suggest an interplay between ageing, regeneration, and immunology, offering avenues for combating age-related diseases and promoting healthy ageing. The immune system plays a pivotal role in the process of ageing, with chronic inflammation emerging as a key contributor to age-related pathologies. Understanding the molecular mechanisms underlying immunosenescence, the age-related decline in immune function, has become crucial in the development of interventions to promote healthy ageing.

Age-related diseases, such as Alzheimer’s, cardiovascular disorders, and metabolic diseases, are often characterized by dysregulated inflammation and impaired regenerative processes. Molecular studies have determined signalling pathways and cellular mechanisms involved in ageing, offering targets for therapeutic interventions. Bio-active compounds, derived from natural sources or synthesized, and physical activity have shown potential in modulating these pathways, providing avenues for developing anti-ageing interventions.

Regenerative medicine holds promise for addressing age-related tissue degeneration and promoting longevity. Molecular approaches aim to elucidate the mechanisms driving tissue regeneration, including stem cell biology, tissue engineering, and gene therapy. By harnessing the body’s innate regenerative capacity, innovative therapies for age-related conditions can be designed.

In this Special Issue, molecular advances in ageing and regeneration offer a multifaceted approach to combating age-related diseases and promoting healthy ageing. By determining the complex interplay between immunology, inflammation, and the molecular mechanisms of ageing, novel therapeutic strategies can be aimed at extending health span and enhancing quality of life in the ageing population.

Dr. Jack Feehan
Guest Editor

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• immunology
• inflammation
• ageing diseases
• healthy ageing
• metabolic diseases
• molecular mechanisms of ageing
• bio-actives
• physical activity
• regeneration