Neurobiology: Current Insights into Ischemic Stroke
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 1497
Special Issue Editor
Interests: ischemic stroke; animal models; blood brain-barrier dysfunction; ischemic brain damage; neuroprotection; new therapies; magnetic resonance imaging
Special Issue Information
Dear Colleagues,
Stroke remains a global leading cause of death and permanent disability. Ischemic stroke (about 85% of all strokes) accounts for around 6.5 million deaths per year and by 2030 will result in the annual incidence of over 200 million cases of death or disability globally. Nowadays, pharmacological reperfusion therapies based on the use of the recombinant tissue plasminogen activator (rtPA), a protein involved in the breakdown of blood clots, remains the routine treatment during the acute phase of ischemic stroke (therapeutic window ≤4.5 h). However, rtPA-based treatment is only applicable to <10–30% of patients due to hemorrhagic transformation risk, and toxicity. Alternatively, recanalization could be carried out via mechanical thrombectomy with a total incidence of <20%. This opens opportunities for the reevaluation of the entire chain of stroke care delivery, including prevention, diagnosis, neuroprotection, and neuroreparation in the context of the neurovascular unit.
The present Special Issue welcomes papers on ischemic stroke, with special focus on, but not limited to, preclinical and clinical studies whose results could pave the way for prevention, accurate diagnostics, as well as effective neuroprotection. A non-exclusive list of topics includes the improvement of recanalization therapies, new thrombolytic agents, and reevaluation of neuroprotective compounds in the light of new standards for rigorous preclinical testing. Finally, research works based on molecular imaging or new biomarkers for diagnosis, prognosis, and evaluation of ischemic damage are suitable for this issue.
Dr. Ramón Iglesias-Rey
Guest Editor
Manuscript Submission Information
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Keywords
- animal models
- ischemic stroke
- neuroimaging
- biomarkers
- molecular imaging
- neuroprotection
- prognosis
- clinical data
- poor outcome
