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IJMS
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Sleep Apnea and Intermittent Hypoxia
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Sleep Apnea and Intermittent Hypoxia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1929

Special Issue Editor

Prof. Dr. Zoran Đogaš

E-Mail Website
Guest Editor
Department of Neuroscience and Split Sleep Medicine Center, University of Split School of Medicine, 21000 Split, Croatia
Interests: neuroscience; neurophysiology and neuropharmacology of the respiratory control; GABAA and glutamate receptors; sleep medicine; obstructive sleep apnea; intermittent hypoxia

Special Issue Information

Dear Colleagues,

We would like to publish the special issue on sleep apnea and intermittent hypoxia with the emphasis on the experimental data from both acute and chronic intermittent hypoxia studies serving as a model for studying sleep apnea in humans, as well as from the clinical human studies on the obstructive sleep apnea (OSA) patients where biological markers were measured.

We would be interested in both acute and chronic intermittent hypoxia effects on respiration and sympathetic activity, as well as on different biological markers, and possibly exploring the difference between the two types of experimental hypoxia.

We would strongly support receiving your study data on OSA patients' blood samples targeting some biomarkers, such as inflammatory and metabolic ones, but also those from DNA, proteins and glycans.

IJMS is a journal of molecular science, so pure clinical studies are not suitable, but biomolecular experimental studies are welcome. We are pleased to invite you to participate in this Special Issue through research articles, comprehensive reviews. We will pay special attention on your submission.

Prof. Dr. Zoran Đogaš
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sleep-disordered breathing
  • respiration
  • inflammation
  • molecular and neurophysiological mechanisms of sleep
  • sleep apnea, intermittent hypoxia

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Published Papers (1 paper)

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Research

12 pages, 282 KiB  
Article
The Complex Relationship between Neuromodulators, Circadian Rhythms, and Insomnia in Patients with Obstructive Sleep Apnea
by Agata Gabryelska, Szymon Turkiewicz, Marta Ditmer, Adrian Gajewski, Dominik Strzelecki, Piotr Białasiewicz, Maciej Chałubiński and Marcin Sochal
Int. J. Mol. Sci. 2024, 25(15), 8469; https://doi.org/10.3390/ijms25158469 - 2 Aug 2024
Viewed by 1350
Abstract
Obstructive sleep apnea (OSA) has been linked to disruptions in circadian rhythm and neurotrophin (NFT) signaling. This study explored the link between neuromodulators, chronotype, and insomnia in OSA. The participants (n = 166) underwent polysomnography (PSG) before being categorized into either the control [...] Read more.
Obstructive sleep apnea (OSA) has been linked to disruptions in circadian rhythm and neurotrophin (NFT) signaling. This study explored the link between neuromodulators, chronotype, and insomnia in OSA. The participants (n = 166) underwent polysomnography (PSG) before being categorized into either the control or the OSA group. The following questionnaires were completed: Insomnia Severity Index (ISI), Epworth Sleepiness Scale, Chronotype Questionnaire (morningness-eveningness (ME), and subjective amplitude (AM). Blood samples were collected post-PSG for protein level assessment using ELISA kits for brain-derived neurotrophic factor (BDNF), proBDNF, glial-cell-line-derived neurotrophic factor, NFT3, and NFT4. Gene expression was analyzed utilizing qRT-PCR. No significant differences were found in neuromodulator levels between OSA patients and controls. The controls with insomnia exhibited elevated neuromodulator gene expression (p < 0.05). In the non-insomnia individuals, BDNF and NTF3 expression was increased in the OSA group compared to controls (p = 0.007 for both); there were no significant differences between the insomnia groups. The ISI scores positively correlated with all gene expressions in both groups, except for NTF4 in OSA (R = 0.127, p = 0.172). AM and ME were predicting factors for the ISI score and clinically significant insomnia (p < 0.05 for both groups). Compromised compensatory mechanisms in OSA may exacerbate insomnia. The correlation between chronotype and NFT expression highlights the role of circadian misalignments in sleep disruptions. Full article
(This article belongs to the Special Issue Sleep Apnea and Intermittent Hypoxia)
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