Cytokines in Lysosomal Storage Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3832
Special Issue Editor
Interests: genetic and neurodegenerative diseases; complement; cytokines; innate and adaptive immunity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In many of the lysosomal storage diseases (LSDs), including the Gaucher, Fabry, Tay–Sachs, Sandhoff, Niemann–Pick, Farbar, Krabbe, Metachromatic Leukodystrophy, Wolmen, and Mucopolysaccharidoses diseases, the pathological consequences of the accumulation of certain lipids and complex sugars in tissues include the generation of a massive amount of pro-inflammatory cytokines, including interleukin-1α (IL-1α), interleukin-1β (IL-β), tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), IL-6, IL-8, IL-10, IL-12, and IL-17. These cytokines are linked to the inflammation and destruction of tissue (e.g., liver, spleen, lung, kidney, bone, and brain tissue) in LSDs. The cost to treat most LSD patients with enzyme replacement or substrate reduction therapy is very expensive: approximately $100,000–300,000 per year. The effects of such therapies are limited as they decrease the accumulation of several types of lipids and complex sugars in tissues but are less effective at preventing the innate and adaptive immune inflammation that leads to organ dysfunction and destruction in LSDs. It is clear that additional therapies are needed to address major disease manifestations. In this Special Issue, we aim to systematically survey recently identified cytokines and their role in the propagation of disease complications in different LSDs. Clinical strategies for targeting cytokines and/or their receptors could help us to slow down and/or stop lipid- and complex-sugar-induced tissue inflammation in different LSDs.
Dr. Manoj K. Pandey
Guest Editor
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