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Special Issue "Molecular Circuits Regulating Sleep and Wakeful Consciousness"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editors

Prof. Dr. Michael Lazarus
E-Mail Website
Guest Editor
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan
Interests: sleep; motivation; arousal; sleep function; neural circuits; opto-biology/pharmacology
Dr. Wang Yi-Qun
E-Mail Website
Guest Editor
Department of Pharmacology, School of Basic Medical Sciences of Fudan University, Fudan University, Shanghai, China
Interests: REM sleep regulation; REM sleep function; sleep-related olfaction

Special Issue Information

Dear Colleagues,

The sleep field has recently witnessed an exponential increase in the understanding of brain circuitries regulating sleep/wake behavior. However, it remains puzzling that brain circuits’ switching occurs within seconds, while sleep regulation (i.e., the process of the accumulation/dissipation of sleep need) takes hours. The teleological problem of sleep regulation and function arises from the presumption of sleep’s evolution from a default state of waking. Humans are likely biased towards this presumption by the egocentricity of waking consciousness. The goal of the Special Issue is to gather original research and review articles relevant to the control of non-rapid eye movement (non-REM), REM sleep, or wakeful consciousness. We are especially seeking contributions that shed light on mechanisms underlying key aspects of the sleep states, such as sleep need; the circadian, ultradian, or behavioral gating of sleep; and REM sleep homeostasis. We are open to articles that use innovative techniques to study the detailed circuit and synaptic basis of sleep/wake control, for example, electrophysiological recording or imaging used in combination with pharmacologic or the genetically driven perturbation of defined sets of neurons or glial cells in all animals that have the ability to sleep or exhibit a sleep-like behavior. We also welcome studies on the molecular profiling of sleep and wake states or the crosstalk between sleep and peripheral physiological systems (e.g., immune system or metabolism), as well as studies about physical and chemical factors that influence sleep and wakefulness.

Prof. Dr. Michael Lazarus
Dr. Wang Yi-Qun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • sleep
  • sleep function
  • glia–neuron interaction
  • molecular circuits
  • sleep homeostasis
  • arousal
  • slow-wave sleep
  • REM sleep
  • physical or chemical sleep/wake factors

Published Papers

This special issue is now open for submission.
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