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Cell Therapy Approaches for Bone and Cartilage Regeneration 2.0
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Cell Therapy Approaches for Bone and Cartilage Regeneration 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 8222

Special Issue Editor

Dr. M. R. Doran

E-Mail Website
Guest Editor
Stem Cell Therapies Laboratory, Queensland University of Technology, Translational Research Institute, Brisbane, QLD 4102, Australia
Interests: repair cartilage; improve umbilical cord blood stem cell transplantation outcomes; develop new methods to study prostate cancer disease in cell culture and in animal models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will consider articles that discuss the use of stem cells, stromal cells, or genetically modified cell populations, used alone or in combination with biomaterials to repair cartilage or bone tissue.

In addition, we welcome detailed investigations into the biology of mesenchymal stem/stromal cell populations, strategies to control phenotypes, or methods to amplify cell potential via genetic modification.

The recent clinical and commercial success of gene and cell therapies, such as CAR T-cells, will likely continue to drive shifts in regulatory frameworks designed to fast-track safe and efficacious cell-based therapies.

We hope that contribution to this collection of articles, at this interesting time in biomedical history, will be a positive experience for you and for the regenerative medicine community. If you are in a position to share your research, we invite you to contribute to this Special Issue on “Cell therapy approaches for bone and cartilage regeneration 2.0”.

Dr. M. R. Doran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesenchymal stem cell
  • regenerative medicine
  • cartilage
  • bone
  • differentiation
  • gene therapy
  • cell therapy
  • tissue engineering
  • stem cell
  • biomaterials

Related Special Issue

Published Papers (3 papers)

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Research

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15 pages, 2303 KiB  
Article
The Role of Synovial Membrane in the Development of a Potential In Vitro Model of Osteoarthritis
by Denisa Harvanova, Jana Matejova, Lucia Slovinska, Marek Lacko, Slavomira Gulova, Livia Kolesar Fecskeova, Jana Janockova, Timea Spakova and Jan Rosocha
Int. J. Mol. Sci. 2022, 23(5), 2475; https://doi.org/10.3390/ijms23052475 - 24 Feb 2022
Cited by 2 | Viewed by 2137
Abstract
There is a lack of in vitro models able to plausibly represent the inflammation microenvironment of knee osteoarthritis (OA). We analyzed the molecules released from OA tissues (synovial membrane, cartilage, infrapatellar fat pad) and investigated whether the stimulation of human synovial fibroblasts (SFs), [...] Read more.
There is a lack of in vitro models able to plausibly represent the inflammation microenvironment of knee osteoarthritis (OA). We analyzed the molecules released from OA tissues (synovial membrane, cartilage, infrapatellar fat pad) and investigated whether the stimulation of human synovial fibroblasts (SFs), with synthetic cytokines (IL-1β and TNF-α or IFN-γ) or conditioned media (CM) from OA tissues, influence the SFs’ response, in the sense of pro-inflammatory cytokines, chemokines, growth factors, and degradative enzymes modulation. Human SFs were obtained from OA synovial membranes. SFs and their CM were analyzed for biomarkers, proliferation rate, protein profile and gene expression, before and after stimulation. Real-time PCR and multiplex assays quantified OA-related gene expression and biomolecule production. Unlike other activators, CM from OA synovial membrane (CM-SM), significantly up-regulated all genes of interest (IL-6, IL-8, MMP-1, MMP-3, RANTES, MCP-1, TSG-6, YKL-40) in SFs. Multiplex immunoassay analysis showed that levels of OA-related cytokines (IL-6, IL-8, MCP 1, IL-1Ra), chemokine (RANTES) and growth factor (VEGF), produced by CM-SM stimulated SFs, increased significantly compared to non-stimulated SFs. Molecules released from the SM from OA patients induces OA-like changes in vitro, in specific OA synovial populations (SFs). These findings promote the use and establish a compelling in vitro model that simulates the versatility and complexity of the OA disease. This model, in the future, will allow us to study new cell therapies or test drugs by reducing or avoiding animal models. Full article
(This article belongs to the Special Issue Cell Therapy Approaches for Bone and Cartilage Regeneration 2.0)
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15 pages, 4080 KiB  
Article
Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration
by Sa Cha, Sueng-Min Lee, Jiangyue Wang, Qing Zhao and Ding Bai
Int. J. Mol. Sci. 2021, 22(19), 10632; https://doi.org/10.3390/ijms221910632 - 30 Sep 2021
Cited by 7 | Viewed by 2162
Abstract
Aging has been proven to be one of the major causes of temporomandibular joint (TMJ) disability and pain in older people. Peripheral circadian rhythms play a crucial role in endochondral ossification and chondrogenesis. However, the age-related alterations of circadian clock in TMJ structures [...] Read more.
Aging has been proven to be one of the major causes of temporomandibular joint (TMJ) disability and pain in older people. Peripheral circadian rhythms play a crucial role in endochondral ossification and chondrogenesis. However, the age-related alterations of circadian clock in TMJ structures are seldom reported. In the current study, TMJ condyles were extracted from young (4-month-old), middle-aged (10-month-old), and old-aged (20-month-old) adults to detect the morphology and circadian oscillation changes in TMJ condyles with aging. The transcriptome profile of Bmal1-deleted bone-marrow mesenchymal stem cells (BMSCs) and controls were explored to reveal the circadian-related differences at the molecular level. Furthermore, the reparative effects of Bmal1-overexpressed BMSCs-based cytotherapy in aged TMJ condyles were investigated in vitro and in vivo. Aged TMJ condyles displayed damaged tissue structure and an abolished circadian rhythm, accompanied by a progressively decreasing chondrogenesis capability and bone turnover activities. The deletion of Bmal1 significantly down-regulated chondrogenesis-related genes Prg4, Sox9, and Col7a1. Bmal1-overexpressed BMSCs presented improved migration capability ex vivo and attenuated age-related TMJ condylar degeneration in vivo. These data demonstrate the crucial role of circadian timing in the maintenance of osteochondral homeostasis, and indicate the potential clinical prospects of circadian-modified MSCs therapy in tissue regeneration. Full article
(This article belongs to the Special Issue Cell Therapy Approaches for Bone and Cartilage Regeneration 2.0)
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Review

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21 pages, 2121 KiB  
Review
Method Categorization of Stem Cell Therapy for Degenerative Osteoarthritis of the Knee: A Review
by Jae Sun Lee, Dong Woo Shim, Kyung-Yil Kang, Dong-Sik Chae and Woo-Suk Lee
Int. J. Mol. Sci. 2021, 22(24), 13323; https://doi.org/10.3390/ijms222413323 - 11 Dec 2021
Cited by 5 | Viewed by 3395
Abstract
Current clinical applications of mesenchymal stem cell therapy for osteoarthritis lack consistency because there are no established criteria for clinical processes. We aimed to systematically organize stem cell treatment methods by reviewing the literature. The treatment methods used in 27 clinical trials were [...] Read more.
Current clinical applications of mesenchymal stem cell therapy for osteoarthritis lack consistency because there are no established criteria for clinical processes. We aimed to systematically organize stem cell treatment methods by reviewing the literature. The treatment methods used in 27 clinical trials were examined and reviewed. The clinical processes were separated into seven categories: cell donor, cell source, cell preparation, delivery methods, lesion preparation, concomitant procedures, and evaluation. Stem cell donors were sub-classified as autologous and allogeneic, and stem cell sources included bone marrow, adipose tissue, peripheral blood, synovium, placenta, and umbilical cord. Mesenchymal stem cells can be prepared by the expansion or isolation process and attached directly to cartilage defects using matrices or injected into joints under arthroscopic observation. The lesion preparation category can be divided into three subcategories: chondroplasty, microfracture, and subchondral drilling. The concomitant procedure category describes adjuvant surgery, such as high tibial osteotomy. Classification codes were assigned for each subcategory to provide a useful and convenient method for organizing documents associated with stem cell treatment. This classification system will help researchers choose more unified treatment methods, which will facilitate the efficient comparison and verification of future clinical outcomes of stem cell therapy for osteoarthritis. Full article
(This article belongs to the Special Issue Cell Therapy Approaches for Bone and Cartilage Regeneration 2.0)
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