Cellular Mechanism and Immune Response of Colorectal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 6618
Special Issue Editors
Interests: translational research of pipeline compounds in cancer therapy; cancer cell biology; regenerative medicine
Interests: colorectal cancer; non-coding RNAs; biomarkers
Interests: signaling pathways; solid tumors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A Special Issue on the topic “Cellular Mechanism and Immune Response of Colorectal Cancer” is being prepared for the journal IJMS. Colorectal cancer (CRC) is one of the most common malignancies worldwide. The prognosis of colorectal cancer patients remains poor due to the development of tumor cell invasion and metastasis. During tumor development, cell-cell adhesion is the key factor in maintaining the primary tumor. The loss of cell-cell adhesion capacity allows malignant cells to dissociate from the primary tumor, migrate through the blood stream, and invade into the tissues of secondary locations, leading to the formation of metastatic tumors in distant organs. Growing evidence suggests that dysregulation of cell adhesion molecules (CAMs) and evasion of immune surveillance enhances the potential for metastatic spread of tumor cells. Expression of programmed cell death ligand-1 (PD-L1) employed by tumor cells promotes immune evasion through suppression of the T-cell immune function. Therefore, a better understanding of the functional and biochemical mechanisms involved in cell-cell adhesion defects and impaired immune anti-tumor activity is crucial for developing new treatment strategies and markers predictive of colorectal cancer metastasis.
In this Special Issue, I invite you to submit original manuscripts and reviews that focus on the molecular basis and advances of cell-cell adhesion and immune response in colorectal cancer progression and metastasis.
Dr. Ariel Ka Man Chow
Dr. Lui Ng
Dr. Rebecca Chin
Guest Editors
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Keywords
- cancer
- metastasis
- invasion
- cell-cell adhesion
- cell-matrix adhesion
- cell adhesion molecules
- immune evasion
- immune response
- immunosuppressive cells
- programmed cell death ligand 1 (PD-L1)
- programmed cell death protein 1 (PD1)
- T cell
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