Impact of Dyslipidemia and Metabolic Syndrome on Cardiac Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3069
Special Issue Editor
Special Issue Information
Dear Colleagues,
Dyslipemia and metabolic syndrome are considered established risk factors for cardiovascular diseases. The metabolic syndrome dyslipidemia is characterized by high levels of triglycerides and apolipoprotein (apo) B-100-rich particles of a particularly atherogenic phenotype (small dense low-density lipoprotein-cholesterol (LDL-C)), and low levels of high-density lipoprotein-cholesterol (HDL-C). One of the common phenotypic characteristics that define the impact of dyslipidemia and metabolic syndrome on the heart is the accumulation of lipids in the form of lipid droplets into the cardiomyocytes. There are different mechanisms involved in this pathophysiological mechanism, ranging from alterations in fatty acid uptake and oxidation caused by impaired insulin signaling, to alterations in the lipoprotein profile and lipoprotein receptors involved in lipid uptake. Signal pathways modulating autophagy, and in particular lipophagy, play an essential role in cardiac dysfunction associated with dyslipemia and metabolic syndrome. An intense debate exists about the pro- or anti-inflammatory role of lipid droplets under specific circumstances. What it is clear is that the modulation of lipid droplet formation and lipid droplet composition offers key therapeutic opportunities to preserve cardiac functionality.
Dr. Vicenta Llorente-Cortés
Guest Editor
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Keywords
- lipid management
- lipoprotein receptors
- insulin resistance
- lipophagy
- fatty acids
- lipid droplets
- triglyceride
- cholesteryl esters
