Carbonic Anhydrase and Hypoxia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 3206
Special Issue Editor
Interests: carbonic anhydrases; hypoxia; tumor microenvironment; metabolon; monoclonal antibodies; oxygen consumption
Special Issue Information
Dear Colleagues,
Hypoxia is a key phenomenon associated not only with tumors but cardiovascular diseases as well. Its importance in physiological processes was raised by the Nobel prize winners in Physiology or Medicine in 2019. However, there are other factors of great significance, such as the “old-fashioned” enzymes, which are inevitably involved in disease progression.
Among the family of carbonic anhydrases, CAIX and CAXII used to be considered the enzymes regulated by hypoxia. It now seems there are other enzymes, isotopes of this family (e.g., CAII or CAIII), which may also be the game changers. Therefore, I believe that this Special Issue should be broadly conceived and targeted toward the role of carbonic anhydrases in hypoxia, with a primary focus on the regulators of their enzymatic activity.
We should concentrate on studies which are engaged in the relevance of hypoxia in the activity of these enzymes.
Besides basic research I also suggest a focus on diagnostics and therapy, and call in experts in physiological hypoxia or inhibitors (SMIs or antibodies).
Prof. Dr. Jaromír Pastorek
Guest Editor
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