Molecular Drivers of Responsiveness to Cancer Immunotherapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 13390
Special Issue Editors
Interests: mechanisms of immunosuppression; cannabinoid receptors; tumor immunology; anti-cancer vaccines; immunotherapeutics; immunosuppressive myeloid cells (MDSC)
Interests: tumor immunology; immunotherapy resistance; immune monitoring
Special Issue Information
Dear Colleagues,
Cancer immunotherapeutics such as cancer vaccines and immune checkpoint inhibitors act by activating the immune system against cancer. Despite recent advances and encouraging successes, the pressing problem is the resistance to these treatments in the majority of patients; for example, only <10–15% of patients respond to checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4. Therefore, understanding the mechanisms of resistance to immunotherapy as well as developing treatments to overcome resistance and improve responsiveness are critical areas of research. This Special Issue of the International Journal of Molecular Sciences will discuss emerging concepts in these areas. The topics will encompass molecular and cellular mechanisms of resistance to checkpoint blockade and anti-tumor vaccines, innate and acquired resistance, pathways of immunosuppression including suppressor cell populations, and approaches combining chemo-radiation or other targeted treatments to improve immunotherapy responsiveness and overall efficacy.
Dr. Venkatesh Hegde
Dr. Stephanie M. Dorta-Estremera
Guest Editors
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Keywords
- cancer vaccines
- checkpoint blockade
- cytokines and chemokines
- immunosuppression
- immunotherapy resistance
- suppressor cells
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