Epigenetic Mechanisms and Potential Therapeutic Strategies in Multiple Sclerosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 1677
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue focuses on studies investigating the gene-environment influences and epigenetic alterations underlying multiple sclerosis’ (MS) etiology or pathology. These can include animal models or clinical studies. Many studies have identified changes in the one-carbon metabolism, histone and DNA methylation, and noncoding RNA in MS. The role of the microbiome on epigenetic changes is also an area of interest. We welcome studies that delve into the mechanisms involved in epigenetic changes in MS and the resultant aberrant transcriptions in neurons, oligodendrocytes, astrocytes, microglia, or other peripheral cells in addition. We also aim to cover potential therapies that can restore appropriate epigenetic control considering the neuroinflammatory, autoimmune, and neurodegenerative aspects of this disease. These therapies could include dietary factors, exercise, and others.
Dr. Jennifer McDonough
Guest Editor
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Keywords
- multiple sclerosis
- epigenetics
- neuroinflammation
- DNA methylation
- noncoding RNA
- microbiome
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