Innate Immunity and Related Pathways in Leukemia Cells and Their Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 4
Special Issue Editor
Interests: acute myeloid leukemia; acute lymphoblastic leukemia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the impact of diverse stimuli and associated signaling pathways— particularly those linked to innate immunity and inflammation—on leukemia cells and their microenvironment.
In particular, inflammation triggers epigenetic mechanisms that affect not only leukemia cell phenotypes but also the cells of the leukemia microenvironment.
For example, changes in the expression of inflammatory cytokines affect mesenchymal cells, epithelial cells, endothelial cells, stem and progenitor phenotypes, diverse immune cell types, as well as almost every cell type endowed with receptors for cytokines that are either exposed on the cell surface or secreted.
Taken together, inflammation-triggered stimuli and their associated signaling pathways impact cell phenotypes that are relevant to the course of leukemia.
Evolving novel technologies are expected to drive a new wave of discoveries. However, it is important to note that the products of novel technologies cannot be expected to facilitate progress in the health sector unless effective controls and validation methods ensure the results are meaningful and can be used to spur translational and preclinical research into trustworthy tools and methods.
The insights gained, together with the quality, accuracy, and precision of the validation methods, are expected to form the basis of progress in this field.
Papers addressing the effects of inflammation on leukemia cells and their microenvironment are welcome.
Dr. Spiros Vlahopoulos
Guest Editor
Manuscript Submission Information
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Keywords
- leukemia
- innate immunity
- inflammation
- signaling pathways
- microenvironment
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