Molecular Research on Biomarker and Proteomics Analysis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (5 February 2024) | Viewed by 2591
Special Issue Editor
Special Issue Information
Dear Colleagues,
Proteomics began in the mid-1990s, followed by metabolomics, which has emerged thereafter, and genomics, which is still evolving, and the technological development of these comprehensive analyses continues unabated. With such significant progress in the information obtained from omics, we have moved from the past era in which diseases were classified based on patients' own complaints, physicians' observations, anatomy, and histology, to an era in which diseases are determined at the molecular level, such as genes. With this shift, we are moving away from the one-size-fits-all approach of treating many people in the same way to an era of precision medicine that takes into account differences in individual genetic and environmental factors. In this precision medicine, precise diagnosis and clinical trials based on biomarkers are indispensable.
To study human diseases, it is direct to analyze human samples, not cells or animals. Tumor tissue is relatively easy to obtain for cancer, but for many diseases, such as hypertension and psychiatric disorders, the site of the lesion is not clear or difficult to obtain. Furthermore, biological samples that are difficult to obtain repeatedly, such as biopsies, are not suitable for studying changes over time. In other words, the availability of human samples is limited to blood, urine, etc. Therefore, disease-related biomarkers obtained from omics analysis conducted on disease model animals or cells should be measured in humans to verify hypotheses and lead to disease treatment or prevention, or biomarker measurement can be used as a diagnostic method.
This special issue discusses the latest research on how biomarker data can be applied to human patients and how to find appropriate biomarkers. Also includes research on MS analysis for multi-omics, development of basic MS techniques to facilitate biomarker determination, and new methods to improve MS data analysis.
Dr. Yoshiya Oda
Guest Editor
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Keywords
- biomarker
- proteomics
- genomics
- transcriptomics
- precision medicine
- multi-omics
- mass spectrometry analysis
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