Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
4.9
Journals
IJMS
Special Issues
Pesticide Exposure and Toxicity: 2nd Edition
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Pesticide Exposure and Toxicity: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 6910

Special Issue Editor

Prof. Dr. Kuenyuh Wu

E-Mail Website
Guest Editor
1. Institute of Food Safety and Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan
2. Department of Public Health, College of Public Health, National Taiwan University, Taipei 10055, Taiwan
3. Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei 10055, Taiwan
Interests: biomarker; risk assessment; toxicology; metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With increases in the use of agricultural pesticides to continuously improve the quality and yields of crops, the general public can simultaneously be exposed to multiple pesticides through the inhalation of air and the consumption of food and water. The potential health effects of pesticides are of great concern. The assessment of co-exposures to multiple pesticides and corresponding health risks will require the integration of toxicological mechanisms of individual pesticides to establish their mode of action for cumulative assessment. Probabilistic cumulative exposure assessment through multiple media and routes can be performed to characterize the variability of exposures and associated risks for the study population, and sensitivity analysis can be conducted to identify the significant parameters associated with exposures and risks. The results of these assessments will reveal the effects of cumulative exposures to multiple pesticides and potential health risks in the daily life of the general public as well as the measures to reduce exposure and risks.

Prof. Dr. Kuenyuh Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple pesticides
  • cumulative assessment
  • probabilistic assessment
  • mechanisms of molecular toxicology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

22 pages, 5577 KiB  
Article
Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells
by Antonella Mazzone, Ylenia Della Rocca, Federica Flamminii, Simone Guarnieri, Dainelys Guadarrama Bello, Antonio Nanci, Oriana Trubiani, Francesca Diomede and Jacopo Pizzicannella
Int. J. Mol. Sci. 2025, 26(10), 4947; https://doi.org/10.3390/ijms26104947 - 21 May 2025
Viewed by 403
Abstract
Barrier function regulation, angiogenic potential, and immune response modulation are only a few of the many roles of the vascular system that nowadays represent one of the main targets for environmental pollutants, in particular, pesticides. We have used human umbilical vein endothelial cells [...] Read more.
Barrier function regulation, angiogenic potential, and immune response modulation are only a few of the many roles of the vascular system that nowadays represent one of the main targets for environmental pollutants, in particular, pesticides. We have used human umbilical vein endothelial cells (HUVECs) as an in vitro model to investigate the effects of pesticides on the activation of the NALP3-CASP1-IL-1β inflammatory pathway using real time PCR (RT-PCR) and immunofluorescence investigations, reactive oxygen species (ROS) generation, and morphological alterations with scanning electron microscopy (SEM) analysis. Our findings offer a comprehensive evaluation of the cellular and molecular damage induced by pesticide exposure and show strong inflammasome activation. They indicate that these chemicals may initiate necroptosis and drive prolonged inflammation in endothelial cells. This study provides crucial insights into how pesticides contribute to endothelial dysfunction, highlighting the need for further investigation into their inflammatory and immune-modulatory effects on vascular health. Full article
(This article belongs to the Special Issue Pesticide Exposure and Toxicity: 2nd Edition)
►▼ Show Figures

Figure 1

12 pages, 228 KiB  
Article
Residue Monitoring and Risk Assessment of 51 Pesticides in Domestic Shellfish and Seaweed Using GC-MS/MS
by Changkyo Seo, Myungheon Kim, Mihyun Cho, Jaebin Im, Changhyeon Park, Yoonmi Lee, Mi-Ra Jo, Yong-Sun Moon and Moo-Hyeog Im
Int. J. Mol. Sci. 2025, 26(10), 4765; https://doi.org/10.3390/ijms26104765 - 16 May 2025
Viewed by 349
Abstract
Many monitoring studies have been performed to assess and manage the risk of residues in seafood contaminated with pesticides owing to various environmental factors. Although seaweed and shellfish have higher consumption rates than fish, studies on their pesticide residues are limited. Therefore, this [...] Read more.
Many monitoring studies have been performed to assess and manage the risk of residues in seafood contaminated with pesticides owing to various environmental factors. Although seaweed and shellfish have higher consumption rates than fish, studies on their pesticide residues are limited. Therefore, this study aimed to conduct residue monitoring and a risk assessment of 51 pesticides in shellfish (littleneck clam and oyster) and seaweed (sea mustard, seaweed fusiforme, laver, and sea tangle) cultivated in four administrative regions of the Republic of Korea. A total of 120 samples (20 samples per species) were collected, and pesticide residues were analyzed using a modified Quick, Easy, Cheap, Effective, Rugged, and Safe extraction method, followed by a GC-MS/MS analysis. The monitoring results show that oxadiazon was detected at 8–9 ng/g in only four littleneck clam samples. The estimated daily intake was calculated and compared with the acceptable daily intake (ADI) for risk assessment. The %ADI values ranged from 0.05% to 1.12% for average and extreme consumers across six different scenarios. The results of this study suggest that the detected residual levels of pesticides exert no harmful effects on people over a lifetime of consumption. Full article
(This article belongs to the Special Issue Pesticide Exposure and Toxicity: 2nd Edition)
20 pages, 2879 KiB  
Article
Molecular Impact of Sublethal Spinetoram Exposure on Honeybee (Apis mellifera) Larval and Adult Transcriptomes
by Bala Murali Krishna Vasamsetti, Juyeong Kim, Kyongmi Chon, Bo-Seon Kim, Chang-Young Yoon, Sojeong Hwang and Kyeong-Hun Park
Int. J. Mol. Sci. 2024, 25(22), 11923; https://doi.org/10.3390/ijms252211923 - 6 Nov 2024
Cited by 1 | Viewed by 1363
Abstract
Pesticide toxicity is a global concern for honeybee populations, and understanding these effects at the molecular level is critical. This study analyzed the transcriptome of honeybees at larval and adult stages after chronic exposure to a sublethal dose (0.0017 µg a.i./larva) of spinetoram [...] Read more.
Pesticide toxicity is a global concern for honeybee populations, and understanding these effects at the molecular level is critical. This study analyzed the transcriptome of honeybees at larval and adult stages after chronic exposure to a sublethal dose (0.0017 µg a.i./larva) of spinetoram (SPI) during the larval phase. Four groups were used: acetone-treated honeybee larvae (ATL), acetone-treated honeybee adults (ATAs), SPI-treated honeybee larvae (STL), and SPI-treated honeybee adults (STAs). In total, 5719 differentially expressed genes (DEGs) were identified for ATL vs. ATAs, 5754 for STL vs. STAs, 273 for ATL vs. STL, and 203 for ATAs vs. STAs (FC ≤ 1.5, p < 0.05). In response to SPI, 29 unique DEGs were identified in larvae and 42 in adults, with 23 overlapping between comparisons, suggesting genes linked to SPI toxicity. Gene ontology analysis showed that SPI affected metabolism-related genes in larvae and lipid-transport-associated genes in adults. KEGG pathway analysis revealed an enrichment of pathways predominantly associated with metabolism, hormone biosynthesis, and motor proteins in STL. The transcriptomic data were validated by qPCR. These findings demonstrated that SPI disrupts essential molecular processes, potentially harming honeybee development and behavior, underscoring the need for safer agricultural practices. Full article
(This article belongs to the Special Issue Pesticide Exposure and Toxicity: 2nd Edition)
►▼ Show Figures

Figure 1

16 pages, 1831 KiB  
Article
Azoxystrobin Exposure Impacts on Development Status and Physiological Responses of Worker Bees (Apis mellifera L.) from Larval to Pupal Stages
by Xinle Duan, Huanjing Yao, Wenlong Tong, Manqiong Xiong, Shaokang Huang and Jianghong Li
Int. J. Mol. Sci. 2024, 25(21), 11806; https://doi.org/10.3390/ijms252111806 - 3 Nov 2024
Cited by 2 | Viewed by 1584
Abstract
Honeybee larvae and pupae form the cornerstone of colony survival, development, and reproduction. Azoxystrobin is an effective strobilurin fungicide that is applied during the flowering stage for controlling plant pathogens. The contaminated nectar and pollen resulting from its application are collected by forager [...] Read more.
Honeybee larvae and pupae form the cornerstone of colony survival, development, and reproduction. Azoxystrobin is an effective strobilurin fungicide that is applied during the flowering stage for controlling plant pathogens. The contaminated nectar and pollen resulting from its application are collected by forager bees and impact the health of honeybee larvae and pupae. The current study evaluated the survival, development, and physiological effects of azoxystrobin exposure on the larvae and pupae of Apis mellifera worker bees. The field-recommended concentrations of azoxystrobin were found to suppress the survival indices and lifespan in the larval as well as pupal stages; moreover, the rates of the survival and pupation of larvae as well as the body weights of the pupae and newly-emerged adult bees were significantly reduced upon long-term exposure to azoxystrobin. In addition, azoxystrobin ingestion induced changes in the expression of genes critical for the development, immunity, and nutrient metabolism of larvae and pupae, although the expression profile of these genes differed between the larval and pupal stages. Results indicated the chronic toxicity of azoxystrobin on the growth and development of honeybee larvae and pupae, which would affect their sensitivity to pathogens and other external stresses during the development stage and the study will provide vital information regarding the pollination safety and rational use of pesticides. Full article
(This article belongs to the Special Issue Pesticide Exposure and Toxicity: 2nd Edition)
►▼ Show Figures

Figure 1

21 pages, 12472 KiB  
Article
Chromosomal Damage, Chromosome Instability, and Polymorphisms in GSTP1 and XRCC1 as Biomarkers of Effect and Susceptibility in Farmers Exposed to Pesticides
by Fernando Aldana-Salazar, Nelson Rangel, María José Rodríguez, César Baracaldo, María Martínez-Agüero and Milena Rondón-Lagos
Int. J. Mol. Sci. 2024, 25(8), 4167; https://doi.org/10.3390/ijms25084167 - 10 Apr 2024
Viewed by 2211
Abstract
In the department of Boyacá, Colombia, agriculture stands as one of the primary economic activities. However, the escalating utilization of pesticides within this sector has sparked concern regarding its potential correlation with elevated risks of genotoxicity, chromosomal alterations, and carcinogenesis. Furthermore, pesticides have [...] Read more.
In the department of Boyacá, Colombia, agriculture stands as one of the primary economic activities. However, the escalating utilization of pesticides within this sector has sparked concern regarding its potential correlation with elevated risks of genotoxicity, chromosomal alterations, and carcinogenesis. Furthermore, pesticides have been associated with a broad spectrum of genetic polymorphisms that impact pivotal genes involved in pesticide metabolism and DNA repair, among other processes. Nonetheless, our understanding of the genotoxic effects of pesticides on the chromosomes (as biomarkers of effect) in exposed farmers and the impact of genetic polymorphisms (as susceptibility biomarkers) on the increased risk of chromosomal damage is still limited. The aim of our study was to evaluate chromosomal alterations, chromosomal instability, and clonal heterogeneity, as well as the presence of polymorphic variants in the GSTP1 and XRCC1 genes, in peripheral blood samples of farmers occupationally exposed to pesticides in Aquitania, Colombia, and in an unexposed control group. Our results showed statistically significant differences in the frequency of numerical chromosomal alterations, chromosomal instability, and clonal heterogeneity levels between the exposed and unexposed groups. In addition, we also found a higher frequency of chromosomal instability and clonal heterogeneity in exposed individuals carrying the heterozygous GSTP1 AG and XRCC1 (exon 10) GA genotypes. The evaluation of chromosomal alterations and chromosomal instability resulting from pesticide exposure, combined with the identification of polymorphic variants in the GSTP1 and XRCC1 genes, and further research involving a larger group of individuals exposed to pesticides could enable the identification of effect and susceptibility biomarkers. Such markers could prove valuable for monitoring individuals occupationally exposed to pesticides. Full article
(This article belongs to the Special Issue Pesticide Exposure and Toxicity: 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop