Brain Tumors and Their Microenvironment: Focus on Hypoxia, Oxidative Stress and Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1419
Special Issue Editors
Interests: brain; hypoxia; ischemia; brain tumor; HIFs; imaging; neuroprotection; neuroregeneration
2. UMR CNRS 7021, Laboratory Bioimaging and Pathologies, Tumoral Signaling and Therapeutic Targets, Faculty of Pharmacy, 67401 Illkirch, France
Interests: pediatric high-grade gliomas; advanced Ewing sarcoma or osteosarcoma
Special Issue Information
Dear Colleagues,
The tumor microenvironment (TME) is recognized as an important player and therapeutic target in brain tumors. Each type of tumor has its own TME, and the specificity of the central nervous system is important for taking into account the TME when, for example, regarding the immune response. Different components of the TME in the brain (such as cancer cells, including cancer stem cells, glial cells, neurons, endothelial cells, tumor-infiltrating immune cells, and the extracellular matrix) influence the development and progression of brain tumors and their resistance to anticancer therapies. In addition, among TME features of brain cancers, hypoxia is known to be a poor prognostic factor. It promotes tumor progression through various pathways and induces resistance to cancer treatments including radiotherapy. One of the main cellular responses to hypoxia is the stabilization of the transcription factors, called hypoxia-inducible factors (HIFs). Other factors, such as oxidative stress, determine the formation of a tumor-supportive microenvironment.
This Special Issue, “Brain Tumors and Their Microenvironment: Focus on Hypoxia, Oxidative Stress and Inflammation", aims to give a better characterization of the TME of different aggressive brain tumors, such as glioblastoma and brain metastasis, and its role in tumor growth and treatment response. Therefore, submissions of original research articles or reviews related to the impact of the TME on brain cancer progression and treatment resistance and, in particular, the role of hypoxia, oxidative stress and immunity/inflammation and their interrelationship are encouraged. Various approaches (imaging, transcriptomic, proteomic, etc.) and/or different types of treatment (oxygenation/HIF-related therapies, nanoparticles, different types of radiotherapies, anti- or pro-oxidants, immunotherapies, etc.) will allow us to accumulate the knowledge necessary for the development of new, successful therapeutic approaches for the treatment of brain tumors.
Dr. Myriam Bernaudin
Prof. Dr. Natacha Entz-Werlé
Guest Editors
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Keywords
- brain tumors
- tumor microenvironment
- hypoxia/hypoxic signaling
- oxidative stress/anti- or pro-oxidants
- metabolism
- imaging
- therapeutics
- inflammation/immunity
- radioresistance
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