Drug Discovery for Alzheimer's Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3019
Special Issue Editors
Interests: drug discovery; in silico design; Alzheimer’s disease; neurodegeneration; energy dysregulation; diabetes; insulin signaling; synaptic plasticity; neurotrophins; PPARs; LXR; cofilin; FMO3; gut–brain signaling axis
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) and AD-related dementias (ADRDs) are considered two of the major neurodegenerative disorders and represent the most common causes of dementia. To date, novel disease-modifying therapies have given hope for providing benefits to patients who suffer from these devastating disorders. Currently there are no accepted effective drugs on the market, and therefore new therapeutic solutions are urgently needed. Newer studies suggest that novel therapeutics (drugs, nutritional supplements) could be most impactful in the early-to-moderate stages of disease development. Furthermore, early-stage approaches for Alzheimer’s disease are currently based on genetic predisposition, senolytic aims, diet, and energy-related dysregulation (including insulin signaling).
The current aim of this Special Issue is to offer broad perspectives of the recent development and advances in the field of “Novel approaches for the design and development of therapeutics for Alzheimer’s Disease.” In addition, we welcome the submission of papers working towards the identification of novel therapeutic targets for advancing the knowledge base for potential therapeutic intervention.
We invite researchers to submit original papers and reviews about the discovery of new molecular targets and novel therapies for Alzheimer’s disease.
Dr. Rajesh Amin
Prof. Dr. Vishnu Suppiramaniam
Guest Editors
Manuscript Submission Information
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Keywords
- therapeutics
- design and development
- in silico methodologies
- repurposing of therapeutics
- novel molecules
- Alzheimer’s disease
- genetics
- novel delivery systems and nanoformulations
- identification and validation of new targets
- neurodegeneration
- brain cholesterol modulation and associated signaling processes
- biomarker discovery
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