Transcriptional Regulation of Lifespan, Ageing and Age-Related Pathologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2566
Special Issue Editor
Special Issue Information
Dear Colleagues,
It has recently become apparent that the eukaryotic transcriptome is much more complex than the genome, and it is the finely adjustable gene transcription that determines the diversity, intricacy, and specificity of genetic control of all biological processes in the cell and organism. Transcriptome complexity is determined by cellular and tissue-specific transcriptional levels and sets of gene transcripts.
Complex phenotypes are also primarily controlled via the regulation of the transcriptome. For example, it has long been demonstrated that a special program of gene expression controls the progression of successive stages of development. The influence of gene expression on the aging process is thought to be equally important. It has also recently become apparent that naturally occurring genetic variants associated with various human diseases, including age-related diseases, map onto non-coding parts of the genome and are enriched in regulatory gene regions, suggesting that many causative variants may influence gene expression.
The aim of this Special Issue is to bring together original scientific and review articles that present new data, approaches, and perspectives on the role of transcription regulation, alternative cell-specific and age-specific transcripts, and transcriptional networks in controlling lifespan, aging, and senile diseases.
Suggested topics include but are not limited to:
- Gene expression control as the backbone of lifespan regulation;
- Gene expression profiles associated with aging and age-related pathologies;
- Altering transcription factor binding sites as the basis for variation in lifespan, aging rates, and progression of age-related pathologies;
- Cell-type-specific gene expression levels and patterns in the control of lifespan, aging, and age-related pathologies;
- The role of alternative gene transcripts in controlling lifespan;
- Transcriptional networks regulating lifespan, aging, and age-related pathologies.
Dr. Elena Genrikhovna Pasyukova
Guest Editor
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Keywords
- gene regulation
- gene expression
- transcription factors binding sites
- differential transcription
- alternative gene transcripts
- transcription networks
- lifespan and aging
- age-related pathologies
- complex traits
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