Molecular Mechanisms of Alzheimer’s Disease and Brain Tolerance

Dear Colleagues,

It is well-known that Alzheimer’s disease (AD) is the main cause of dementia and the most prevalent brain disorder in the elderly, being considered a major public health concern worldwide. More than 100 years after the first case report, AD is still an incurable disease with no effective disease-modifying therapies, in part because the etiopathogenesis of this devastating neurogenerative disease remains elusive. In this sense, the Special Issue “Molecular Mechanisms of Alzheimer’s Disease and Brain Tolerance” aims to gather the most recent advances in the field to provide a more comprehensive picture of the molecular basis underlying the selective neuronal degeneration and loss in AD. Furthermore, this Special Issue also intends to describe the endogenous adaptative and pro-survival mechanisms behind brain tolerance (hormesis/conditioning) as promising targets to counteract AD symptomatology and neuropathology in a timely manner.

This Special Issue welcomes the submission of original research or review articles focusing on the cellular and molecular events that contribute to the onset and progression of AD (i.e., vascular dysfunction, brain hypometabolism, mitochondrial dysfunction and oxidative stress, synaptic failure, neuroinflammation, gut dysbiosis, among others) and to brain tolerance against injury.

Dr. Sónia C. Correia
Guest Editor

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