Pathological Changes and Pathogenic Mechanisms of Chronic Liver Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 July 2026 | Viewed by 148
Special Issue Editor
Special Issue Information
Dear Colleagues,
Chronic liver disease (CLD) represents a major global health burden and encompasses a wide spectrum of pathological entities, including metabolic dysfunction–associated steatotic liver disease (MASLD), alcohol-related liver disease, chronic viral hepatitis, autoimmune liver diseases, cholestatic disorders, and their progression to fibrosis, cirrhosis, and hepatocellular carcinoma. Despite their diverse etiologies, these conditions share convergent pathogenic mechanisms involving metabolic dysregulation, chronic inflammation, immune imbalance, oxidative stress, fibrogenesis, and profound alterations in hepatic cellular crosstalk.
This Special Issue, ‘Pathological Changes and Pathogenic Mechanisms of Chronic Liver Disease’, aims to provide an integrated and up-to-date overview of the structural, cellular, molecular, and systemic processes driving liver injury and disease progression. We seek to bridge basic, translational, and clinical research by highlighting how pathological changes at the histological and molecular levels translate into clinical phenotypes and outcomes. Particular emphasis is placed on emerging mechanisms such as immune–metabolic interactions, gut–liver axis dysfunction, mitochondrial and endoplasmic reticulum stress, epigenetic regulation, and novel signaling pathways involved in fibrogenesis and carcinogenesis.
We welcome original research articles, comprehensive reviews, and translational studies that advance the understanding of disease mechanisms, identify novel biomarkers, or explore therapeutic targets relevant to chronic liver disease. By integrating multidisciplinary perspectives, this Special Issue aims to foster innovation and inform future strategies for diagnosis, risk stratification, and treatment.
Dr. Natalia Nuño-Lámbarri
Guest Editor
Manuscript Submission Information
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Keywords
- chronic liver disease
- liver fibrosis
- cirrhosis
- pathogenic mechanisms
- inflammation
- immune–metabolic interactions
- oxidative stress
- gut–liver axis
- hepatocellular carcinoma
- biomarkers
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