Extracellular Vesicles and Nanoparticles 2.0

Dear Colleagues,

After their discovery, extracellular vesicles (EVs—also called “microparticles”) end of 1960s as a product of platelets, they were considered to be degradation products of limited importance. Evs first came in the focus of research about forty years later, and in the year 2012 the first volume in prestigious Journal was issued. This Special Issue of IJMS is to give an additional view in this field. These submicron size vesicles are shed not only from various cell types of multicellular organisms, but also by unicellular ones like Gram positive and Gram negative bacteria. As the product of most eucariotic cells, exosomes are the the most frequently investigated EVs, and they have multiple function, like cell-cell communication, cellular signaling, blood coagulation and homeostasis. However, they seem to be also involved in many pathological processes like tumor growth and invasion, hypertension and vascular injury. EVs that are shed by bacteria and other unicellular organisms were neglected for longer time, and the existence of EVs shed by Gram positive bacteria was even questioned. Now, EVs that are shed by pathogens like bacteria are in the focus of many investigations, especially regarding their role in human diseases.

In this Special Issue, the manuscripts dealing with the new aspects of EVs investigations, especially regarding their isolation and analytics for identification of new disease biomarkers, the role of exosomes and EVs in signal transduction in targeted therapy of several diseases (especially cancer) and in the interaction between the pathogen and host organism. The next point of interest are the microvesicles shed by bacteria and other pathogens and their role in infection and resistance, carrying of toxins and biofilm formation.

Prof. Dr. Djuro Josic
Guest Editor

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• extracellular vesicles
• exosomes
• bacterial toxins
• viruses
• biomarkers
• signal transduction
• targeted therapy
• exososmes in cancer
• exosomes and extracellular vesicles host-pathogen interaction
• extracellular vesicles of gram positive bacteria
• extracellular vesicles of gram negative bacteria
• extracellular vesicles and biofilm formation