Cellular and Molecular Studies of Dopamine and Its Receptors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 May 2024 | Viewed by 642
Special Issue Editor
Special Issue Information
Dear Colleagues,
Dopamine is a neurotransmitter that plays a pivotal role in the brain’s communication system, serving as a chemical messenger that transmits signals between nerve cells and immune cells involved in mood regulation, motivation, reward processing, motor control and peripheral immunity. Dopamine receptors are located on the surface membrane serving as docking sites for dopamine molecules, allowing them to exert their effects on the target cells. There are several types of dopamine receptors, classified into D1-like (D1 and D5) and D2-like (D2, D3, and D4) subtypes, each with distinct functions and signaling pathways. The interaction between dopamine and its receptors is central to numerous physiological processes and has profound implications for pathological conditions such as Parkinson’s disease, schizophrenia, addiction, and mood disorders. Dopamine receptors can also modulate the immune response in various peripheral tissues and organs. Immune cells, such as T cells, B cells, and macrophages, express dopamine receptors. This emerging understanding of the interplay between dopamine, dopamine receptors, and peripheral immunity highlights the multifaceted roles of this neurotransmitter in both the brain and the body, with potential implications for the development of novel therapeutic strategies for various neurological, neuropsychiatric, and immune-related disorders.
Prof. Dr. Habibeh Khoshbouei
Guest Editor
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Keywords
- neuroscience
- dopamine
- dopamine receptors
- peripheral immunity