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Nanomaterials for Cancer Diagnostics and Therapy
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Nanomaterials for Cancer Diagnostics and Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3402

Special Issue Editor

Dr. Ewa Olȩdzka

E-Mail Website
Guest Editor
Department of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland
Interests: nanomaterials; nanomedicine; biomaterials; polymeric drug delivery systems; cancer; nanopharmacy; polymer synthesis and characterization; organometallic catalysts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

I am delighted to invite you to contribute to a Special Issue of the International Journal of Molecular Sciences titled "Nanomaterials for Cancer Diagnostics and Therapy".

Despite significant advancements in medical science, cancer remains one of the world's deadliest diseases. Nanotechnology has made significant contributions to the cancer fight over the last two decades. Nanomaterials, in particular, have emerged as a promising method for improving the efficacy and lowering systemic toxicity of traditional chemotherapeutics. Nanomaterials are at the forefront of the development of new modes of cancer therapy and diagnosis due to their outstanding properties, including cancer immunotherapy, cancer vaccines, and so on.

The multidisciplinary topics of interest for this Special Issue include, but are not limited to, the design, synthesis, and characterization of different types of nanomaterials as drugs, siRNA, etc. delivery systems for cancer therapy and diagnosis. Development and characterization of functional nanomaterials activated by external excitations such as near-infrared light, X-ray, ultrasound, and magnetic fields, as well as translational applications of nanomaterials to preclinical and clinical trials for cancer therapy, are also encouraged. Authors are kindly invited to submit original papers, communications, and reviews.

I look forward to receiving your contributions.

Dr. Ewa Olȩdzka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

18 pages, 6400 KiB  
Article
Improving the Efficacy of Magnetic Nanoparticle-Mediated Hyperthermia Using Trapezoidal Pulsed Electromagnetic Fields as an In Vitro Anticancer Treatment in Melanoma and Glioblastoma Multiforme Cell Lines
by Lilia Souiade, Javier Domingo-Diez, Cesar Alcaide, Berta Gámez, Linarejos Gámez, Milagros Ramos and José Javier Serrano Olmedo
Int. J. Mol. Sci. 2023, 24(21), 15933; https://doi.org/10.3390/ijms242115933 - 03 Nov 2023
Cited by 1 | Viewed by 1149
Abstract
Magnetic hyperthermia (MHT) is an oncological therapy that uses magnetic nanoparticles (MNPs) to generate localized heat under a low-frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMFs) have proven their efficacy in enhancing the efficiency of heating in MHT as [...] Read more.
Magnetic hyperthermia (MHT) is an oncological therapy that uses magnetic nanoparticles (MNPs) to generate localized heat under a low-frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMFs) have proven their efficacy in enhancing the efficiency of heating in MHT as compared to the sinusoidal one. Our study aims to compare the TPAMF waveform’s killing effect against the sinusoidal waveform in B16F10 and CT2A cell lines to determine more efficient waveforms in causing cell death. For that purpose, we used MNPs and different AMF waveforms: trapezoidal (TP), almost-square (TS), triangular (TR), and sinusoidal signal (SN). MNPs at 1 and 4 mg/mL did not affect cell viability during treatment. The exposition of B16F10 and CT2A cells to only AMF showed nonsignificant mortality. Hence, the synergetic effect of the AMF and MNPs causes the observed cell death. Among the explored cases, the nonharmonic signals demonstrated better efficacy than the SN one as an MHT treatment. This study has revealed that the application of TP, TS, or TR waveforms is more efficient and has considerable capability to increase cancer cell death compared to the traditional sinusoidal treatment. Overall, we can conclude that the application of nonharmonic signals enhances MHT treatment efficiency against tumor cells. Full article
(This article belongs to the Special Issue Nanomaterials for Cancer Diagnostics and Therapy)
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20 pages, 4706 KiB  
Article
Effectiveness of Gold Nanorods of Different Sizes in Photothermal Therapy to Eliminate Melanoma and Glioblastoma Cells
by Javier Domingo-Diez, Lilia Souiade, Vanesa Manzaneda-González, Marta Sánchez-Díez, Diego Megias, Andrés Guerrero-Martínez, Carmen Ramírez-Castillejo, Javier Serrano-Olmedo and Milagros Ramos-Gómez
Int. J. Mol. Sci. 2023, 24(17), 13306; https://doi.org/10.3390/ijms241713306 - 27 Aug 2023
Viewed by 1461
Abstract
Gold nanorods are the most commonly used nanoparticles in photothermal therapy for cancer treatment due to their high efficiency in converting light into heat. This study aimed to investigate the efficacy of gold nanorods of different sizes (large and small) in eliminating two [...] Read more.
Gold nanorods are the most commonly used nanoparticles in photothermal therapy for cancer treatment due to their high efficiency in converting light into heat. This study aimed to investigate the efficacy of gold nanorods of different sizes (large and small) in eliminating two types of cancer cell: melanoma and glioblastoma cells. After establishing the optimal concentration of nanoparticles and determining the appropriate time and power of laser irradiation, photothermal therapy was applied to melanoma and glioblastoma cells, resulting in the highly efficient elimination of both cell types. The efficiency of the PTT was evaluated using several methods, including biochemical analysis, fluorescence microscopy, and flow cytometry. The dehydrogenase activity, as well as calcein-propidium iodide and Annexin V staining, were employed to determine the cell viability and the type of cell death triggered by the PTT. The melanoma cells exhibited greater resistance to photothermal therapy, but this resistance was overcome by irradiating cells at physiological temperatures. Our findings revealed that the predominant cell-death pathway activated by the photothermal therapy mediated by gold nanorods was apoptosis. This is advantageous as the presence of apoptotic cells can stimulate antitumoral immunity in vivo. Considering the high efficacy of these gold nanorods in photothermal therapy, large nanoparticles could be useful for biofunctionalization purposes. Large nanorods offer a greater surface area for attaching biomolecules, thereby promoting high sensitivity and specificity in recognizing target cancer cells. Additionally, large nanoparticles could also be beneficial for theranostic applications, involving both therapy and diagnosis, due to their superior detection sensitivity. Full article
(This article belongs to the Special Issue Nanomaterials for Cancer Diagnostics and Therapy)
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