ijms-logo

Journal Browser

Journal Browser

Molecular Basis and Therapies in Neurological Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1211

Special Issue Editor


E-Mail Website
Guest Editor
Department of Neurology and Pediatric Neurology, Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca, Cluj Napoca, Romania
Interests: pediatric neurology; cerebral palsy; neurological disorders; biomarkers; Alzheimer's disease; Parkinson’s; stroke

Special Issue Information

Dear Colleagues,

The Special Issue "Molecular Basis and Therapies in Neurological Disorders" is a collection dedicated to exploring the molecular basis and treatments of neurological diseases.

The Special Issue covers the molecular mechanisms of various neurological diseases, including but not limited to Alzheimer's disease, Parkinson's disease, stroke, etc. In-depth research on the pathogenesis and molecular pathways of these diseases will provide the basis for the development of new treatments. This Special Issue focuses on the latest treatments for neurological diseases, including drug therapy, gene therapy, stem cell therapy, and more. Researchers and clinicians will share their experiences and results in developing new treatments. This Special Issue aims to provide the scientific community with an in-depth understanding of the latest research advances and treatment innovations in neurological diseases.

The Special Issue will include, but is not limited to, the following aspects:

  1. Research on molecular markers: Exploring potential biomarkers to support early diagnosis and personalized treatment.
  2. Gene editing in the treatment of neurological diseases: Assessing the promise and challenges of CRISPR and other gene editing technologies in treating neurological diseases.
  3. Nerve regeneration therapy: Exploring the potential role of stem cells and other regenerative medicine approaches in repairing damaged neural tissue.

All these efforts aim to improve neurological disorder management and consequently achieve a better quality of life for patients.

Dr. Mihaela-Adela Vinţan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological diseases
  • nerve damage
  • Alzheimer's disease
  • Parkinson’s
  • stroke
  • pathogenesis
  • drug treatment
  • nanomedicine delivery
  • gene therapy
  • stem cell therapy
  • therapeutic targets
  • nerve regeneration
  • molecular markers
  • gene editing technology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 906 KiB  
Article
Expression Patterns of SMAD1–8 in the Peripheral Facial Nerve Following Compressive Nerve Injury or Axotomy
by Jae Min Lee, Dong Keon Yon, Sung Soo Kim and Seung Geun Yeo
Int. J. Mol. Sci. 2025, 26(5), 2291; https://doi.org/10.3390/ijms26052291 - 4 Mar 2025
Viewed by 750
Abstract
Facial nerve injury can lead to significant functional impairment, emotional impacts, and difficulties in social and economic activities. Although peripheral nerves have the potential for recovery, incomplete regeneration can pose challenges. Suppressor of Mothers Against Decapentaplegic Homolog (SMAD) proteins are crucial in the [...] Read more.
Facial nerve injury can lead to significant functional impairment, emotional impacts, and difficulties in social and economic activities. Although peripheral nerves have the potential for recovery, incomplete regeneration can pose challenges. Suppressor of Mothers Against Decapentaplegic Homolog (SMAD) proteins are crucial in the nerve-regeneration process. The study aimed to investigate the changes in SMAD protein expression involved in peripheral nerve regeneration following facial nerve injury induced by compression or axotomy in a pre-clinical study conducted on Sprague Dawley rats. Facial nerve recovery was assessed at 1, 2, 3, 4, 8, and 12 weeks post-facial nerve compression and axotomy using behavioral tests, including whisker movement and eyelid blink-reflex tests. Additionally, the role of SMAD proteins in the nerve regeneration process was evaluated by analyzing the expression of SMAD1–8 proteins at 2 and 12 weeks post-injury. Behavioral tests revealed significant impairment in facial nerve function in both the Compression and Axotomy groups compared with the Sham group at early time points. Recovery was observed in the Compression group by 2 weeks, whereas the Axotomy group exhibited prolonged impairment through 12 weeks. SMAD protein analyses showed increased expression of SMAD2, SMAD7, and SMAD8 following compression injury, whereas axotomy led to more extensive increases in expression that included SMAD1, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, and SMAD8. These findings suggest that SMAD proteins play differential roles in nerve regeneration following facial nerve injuries caused by compression versus axotomy. The distinct expression patterns of SMAD proteins highlight their potential as therapeutic targets for enhancing nerve regeneration and functional recovery in peripheral nerve injuries. Full article
(This article belongs to the Special Issue Molecular Basis and Therapies in Neurological Disorders)
Show Figures

Figure 1

Back to TopTop